Anti-Myosin light chain 3抗体[39-15] (ab50070)

概述

• 产品名称
  Anti-Myosin light chain 3抗体[39-15]
  参阅全部 Myosin light chain 3 一抗
• 描述
  小鼠单克隆抗体[39-15] to Myosin light chain 3
• 经测试应用
  适用于: Sandwich ELISA, ELISA, WBmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat
• 免疫原

  Synthetic peptide:

  EVEFDASKIKI

  , corresponding to amino acids 34-44 of Human cardiac Myosin light chain 1

  Run BLAST with Run BLAST with

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• 存储溶液
  Preservative: None
  Constituents: PBS, pH 7.3
• Concentration information loading...
• 纯度
  Protein G purified
• 克隆
  单克隆
• 克隆编号
  39-15
• 同种型
  IgG1
• 轻链类型
  kappa
• 研究领域
  • Signal Transduction
  • Cytoskeleton / ECM
  • Cytoskeleton
  • Motor Proteins
  • Myosin

  • Cardiovascular
  • Heart
  • Contractility
  • Contractile Proteins
  • Myosins

相关产品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

应用

靶标

• 功能
  Regulatory light chain of myosin. Does not bind calcium.
• 疾病相关
  Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic type 8 (CMH8) [MIM:608751]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.
  Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 1 (MVC1) [MIM:608751]. MVC1 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
• 序列相似性
  Contains 3 EF-hand domains.
• 翻译后修饰
  The N-terminus is blocked.
  N-terminus is methylated by METTL11A/NTM1.

• Target information above from: UniProt accession P08590 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 4634 Human
  • Entrez Gene: 17897 Mouse
  • Entrez Gene: 24585 Rat
  • Omim: 160790 Human
  • SwissProt: P08590 Human
  • SwissProt: P09542 Mouse
  • SwissProt: P16409 Rat
  • Unigene: 517939 Human

  • Unigene: 7353 Mouse
  • Unigene: 1955 Rat

  see all
• 别名
  • Cardiac myosin light chain 1 antibody
  • CMH8 antibody
  • CMLC1 antibody

  • ELC of myosin antibody
  • Essential light chain of myosin antibody
  • MLC1SB antibody
  • MLC1V antibody
  • MYL3 antibody
  • MYL3_HUMAN antibody
  • Myosin light chain 1 antibody
  • Myosin light chain 1 slow twitch muscle B/ventricular isoform antibody
  • Myosin light chain 1 slow, B antibody
  • Myosin light chain 3 antibody
  • Myosin, light chain 1, ventricular antibody
  • myosin, light chain 3, alkali; ventricular, skeletal, slow antibody
  • myosin, light polypeptide 3, alkali antibody
  • myosin, light polypeptide 3, alkali; ventricular, skeletal, slow antibody
  • OTTHUMP00000165922 antibody
  • Slow skeletal ventricular myosin alkali light chain 3 antibody
  • slow-twitch muscle B/ventricular isoform antibody
  • Ventricular/slow twitch myosin alkali light chain antibody
  • VLC1 antibody

  see all

实验方案

• Western blot protocols