Anti-Myosin Light Chain 2抗体(ab59301)

概述

  • 产品名称Anti-Myosin Light Chain 2抗体
    参阅全部 Myosin Light Chain 2 一抗
  • 描述
    兔多克隆抗体to Myosin Light Chain 2
  • 特异性Detects endogenous levels of Myosin regulatory light chain 2 protein.
  • 经测试应用适用于: ELISA, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic non-phosphopeptide derived from human Myosin regulatory light chain 2 around the phosphorylation site of serine 18 (A-T-SP-N-V).

  • 阳性对照
    • Human brain tissue

性能

应用

Our Abpromise guarantee covers the use of ab59301 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/5000.
IHC-P Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration. PubMed: 22274911

靶标

  • 疾病相关Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 2 (MVC2) [MIM:608758]. MVC2 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
  • 序列相似性Contains 3 EF-hand domains.
  • 翻译后修饰N-terminus is methylated by METTL11A/NTM1.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cardiac myosin light chain-2 antibody
    • Cardiac ventricular myosin light chain 2 antibody
    • CMH10 antibody
    • MLC 2v antibody
    • MLC-2 antibody
    • MLC-2v antibody
    • MLC2 antibody
    • MLRV_HUMAN antibody
    • MYL 2 antibody
    • MYL2 antibody
    • Myosin light chain 2 regulatory cardiac slow antibody
    • Myosin light polypeptide 2 regulatory cardiac slow antibody
    • Myosin regulatory light chain 2 antibody
    • Myosin regulatory light chain 2 ventricular/cardiac muscle isoform antibody
    • Regulatory light chain of myosin antibody
    • RLC of myosin antibody
    • Slow cardiac myosin regulatory light chain 2 antibody
    • ventricular/cardiac muscle isoform antibody
    see all

Anti-Myosin Light Chain 2 antibody 图像

  • Ab59301 at 1/50-1/100 dilution staining human brain without (left) and with (right) immunizing peptide; paraffin embedded.

Anti-Myosin Light Chain 2 antibody (ab59301)参考文献

This product has been referenced in:
  • Shinozawa T  et al. A novel purification method of murine embryonic stem cell- and human-induced pluripotent stem cell-derived cardiomyocytes by simple manual dissociation. J Biomol Screen 17:683-91 (2012). ICC/IF ; Mouse . Read more (PubMed: 22274911) »
  • Fujita H  et al. Fabrication of scaffold-free contractile skeletal muscle tissue using magnetite-incorporated myogenic C2C12 cells. J Tissue Eng Regen Med 4:437-43 (2010). Read more (PubMed: 20084621) »

See all 2 Publications for this product

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I have obtained some ELISA testing data for ab5930,

An indirect ELISA was performed, using the immunogen peptide as the antigen, with varying dilutions of antibody. The ELISA result is as fol...

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