Anti-Myosin 1C抗体- Carboxyterminal end (ab71486)

概述

• 产品名称Anti-Myosin 1C抗体- Carboxyterminal end
  参阅全部 Myosin 1C 一抗
• 描述
  兔多克隆抗体to Myosin 1C - Carboxyterminal end
• 经测试应用适用于: WB, IHC-P, ELISAmore details
• 种属反应性
  与反应: Human
  
• 阳性对照
  • K562 cell lysate, human prostate carcinoma tissue.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• 存储溶液Preservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• 纯度Protein A purified
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Signal Transduction
  • Cytoskeleton / ECM
  • Cytoskeleton
  • Motor Proteins
  • Myosin

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.
  Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation.
• 序列相似性Contains 2 IQ domains.
  Contains 1 myosin head-like domain.
• 结构域Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to a putative PH domain present in its tail domain.
• 细胞定位Cytoplasm. Cell membrane. Cell projection > stereocilium membrane. Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane. Colocalizes in adipocytes with GLUT4 in actin-based membranes. Localizes transiently at cell membrane to region known to be enriched in PIP2. Activation of phospholipase C results in its redistribution to the cytoplasm and Nucleus > nucleoplasm. Nucleus > nucleolus. Nucleus > nuclear pore complex. Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level.

• Target information above from: UniProt accession O00159 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 4641 Human
  • Omim: 606538 Human
  • SwissProt: O00159 Human
  • Unigene: 286226 Human
• 别名
  • MMI beta antibody
  • MMI-beta antibody
  • MMIb antibody

  • MYO1C antibody
  • MYO1C_HUMAN antibody
  • Myosin I beta antibody
  • Myosin Ic antibody
  • Myosin-Ic antibody
  • MYR2 antibody
  • NMI antibody
  • Nuclear myosin I antibody

  see all