概述

  • 产品名称Anti-Myocilin抗体
    参阅全部 Myocilin 一抗
  • 描述
    兔多克隆抗体to Myocilin
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cynomolgus Monkey
  • 免疫原

    Synthetic peptide:

    SVIHNLQRDSSTQRLDL

    conjugated to KLH, corresponding to N terminal amino acids 69-85 of Human Myocilin

  • 阳性对照
    • Retina tissue

性能

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应用

Our Abpromise guarantee covers the use of ab85842 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能May participate in the obstruction of fluid outflow in the trabecular meshwork.
  • 组织特异性Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma.
  • 疾病相关Defects in MYOC are the cause of primary open angle glaucoma type 1A (GLC1A) [MIM:137750]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
    Defects in MYOC may also contribute to primary congenital glaucoma type 3A (GLC3A) [MIM:231300]. Defects in MYOC may contribute to this phenotype via digenic inheritance. GLC3A is an autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
  • 序列相似性Contains 1 olfactomedin-like domain.
  • 翻译后修饰Different isoforms may arise by post-translational modifications.
    Glycosylated.
    Palmitoylated.
  • 细胞定位Rough endoplasmic reticulum. Secreted. Cell projection > cilium. Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. Also secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GLC1A antibody
    • GPOA antibody
    • JOAG antibody
    • JOAG1 antibody
    • Mutated trabecular meshwork-induced glucocorticoid response protein antibody
    • MYOC antibody
    • MYOC_HUMAN antibody
    • Myocilin antibody
    • Myocilin, trabecular meshwork inducible glucocorticoid antibody
    • TIGR antibody
    • Trabecular meshwork induced glucocorticoid response protein antibody
    • Trabecular meshwork-induced glucocorticoid response protein antibody
    see all

Anti-Myocilin antibody 图像

  • ab85842 at 5 µg/ml staining Myocilin in Formalin-Fixed Paraffin-Embedded Human retina tissue

Anti-Myocilin antibody (ab85842)参考文献

ab85842 has not yet been referenced specifically in any publications.

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