Anti-MYLK2抗体- N-terminal (ab71827)

概述

  • 产品名称Anti-MYLK2抗体- N-terminal
    参阅全部 MYLK2 一抗
  • 描述
    兔多克隆抗体to MYLK2 - N-terminal
  • 经测试应用适用于: ELISA, IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide from the N-terminal region of human MYLK2 conjugated to KLH

  • 阳性对照
    • Jurkat cell lysate. Human hepatocarcinoma tissue.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab71827 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
IHC-P 1/50 - 1/100.
WB 1/100 - 1/500. Detects a band of approximately 55 kDa (predicted molecular weight: 65 kDa).

靶标

  • 功能Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
  • 组织特异性Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
  • 疾病相关Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • 细胞定位Cytoplasm. Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KMLC antibody
    • MLCK antibody
    • MLCK, skeletal/cardiac antibody
    • MLCK2 antibody
    • MYLK 2 antibody
    • MYLK2 antibody
    • MYLK2_HUMAN antibody
    • Myosin light chain kinase 2 antibody
    • Myosin light chain kinase 2 skeletal muscle antibody
    • Myosin light chain kinase 2 skeletal/cardiac muscle antibody
    • MYOSIN LIGHT POLYPEPTIDE KINASE antibody
    • Myosin light polypeptide kinase, skeletal/cardiac antibody
    • Skeletal muscle myosin light chain kinase antibody
    • Skeletal myosin light chain kinase antibody
    • skeletal/cardiac muscle antibody
    • skMLCK antibody
    see all

Anti-MYLK2 antibody - N-terminal 图像

  • Anti-MYLK2 antibody - N-terminal (ab71827) at 1/100 dilution + Jurkat cell lysate at 12.5 µg

    Secondary
    HRP-anti-rabbit

    Predicted band size : 65 kDa
    Observed band size : 55 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 100 kDa,32 kDa,35 kDa,40 kDa. We are unsure as to the identity of these extra bands.
  • ab71827 at 1/50 dilution, staining MYLK2 in human hepatocarcinoma by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and AEC staining.

Anti-MYLK2 antibody - N-terminal (ab71827)参考文献

ab71827 has not yet been referenced specifically in any publications.

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