概述

  • 产品名称Anti-MYLK2抗体
    参阅全部 MYLK2 一抗
  • 描述
    小鼠单克隆抗体to MYLK2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: KLLAKKPPSE ASELTFEGVP MTHSPTDPRP AKAEEGKNIL AESQKEVGEK TPGQAGQAKM QGDTSRGIEF QAVPSEKSEV GQALCLTARE EDCFQILDDC , corresponding to amino acids 161-260 of Human MYLK2

性能

应用

Our Abpromise guarantee covers the use of ab57944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
    • 组织特异性Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
    • 疾病相关Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
      Contains 1 protein kinase domain.
    • 细胞定位Cytoplasm. Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
    • Information by UniProt
    • 数据库链接
    • 别名
      • KMLC antibody
      • MLCK antibody
      • MLCK, skeletal/cardiac antibody
      • MLCK2 antibody
      • MYLK 2 antibody
      • MYLK2 antibody
      • MYLK2_HUMAN antibody
      • Myosin light chain kinase 2 antibody
      • Myosin light chain kinase 2 skeletal muscle antibody
      • Myosin light chain kinase 2 skeletal/cardiac muscle antibody
      • MYOSIN LIGHT POLYPEPTIDE KINASE antibody
      • Myosin light polypeptide kinase, skeletal/cardiac antibody
      • Skeletal muscle myosin light chain kinase antibody
      • Skeletal myosin light chain kinase antibody
      • skeletal/cardiac muscle antibody
      • skMLCK antibody
      see all

    Anti-MYLK2 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57944 MYLK2 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-MYLK2 antibody (ab57944)参考文献

    ab57944 has not yet been referenced specifically in any publications.

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