Anti-MYH2抗体[EPR5280] (ab124937)


  • 产品名称Anti-MYH2抗体[EPR5280]
    参阅全部 MYH2 一抗
  • 描述
    兔单克隆抗体[EPR5280] to MYH2
  • 经测试应用适用于: WBmore details
    不适用于: IHC-P or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive)

  • 阳性对照
    • Mouse muscle, Rat muscle and Human trachea lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab124937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/10000 - 1/50000. Detects a band of approximately 220 kDa (predicted molecular weight: 223 kDa).
  • 应用说明Is unsuitable for IHC-P or IP.
  • 靶标

    • 功能Muscle contraction. Required for cytoskeleton organization.
    • 疾病相关Defects in MYH2 are the cause of inclusion body myopathy type 3 (IBM3) [MIM:605637]. Hereditary inclusion body myopathies constitute a group of neuromuscular disorders characterized by slowly progressive distal and proximal weakness and a typical muscle pathology including rimmed vacuoles and filamentous inclusions. IBM3 is a variant of hereditary inclusion body myopathies and is characterized by autosomal dominant myopathy with joint contracture, ophthalmoplegia and rimmed vacuoles. Morphological analysis of muscle biopsies from patients indicate that the type 2A fibers frequently were abnormal, whereas other fiber types appeared normal.
    • 序列相似性Contains 1 IQ domain.
      Contains 1 myosin head-like domain.
    • 结构域The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
      Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
    • 细胞定位Cytoplasm > myofibril. Thick filaments of the myofibrils.
    • Information by UniProt
    • 数据库链接
    • 别名
      • adult 2 antibody
      • Fast 2a myosin heavy chain antibody
      • IBM3 antibody
      • Inclusion body myopathy 3, autosomal dominant antibody
      • MYH2 antibody
      • MYH2_HUMAN antibody
      • MYH2A antibody
      • MYHas8 antibody
      • MyHC IIa antibody
      • MyHC-2a antibody
      • MyHC-IIa antibody
      • MYHSA2 antibody
      • Myosin heavy chain 2 antibody
      • Myosin heavy chain 2a antibody
      • Myosin heavy chain antibody
      • Myosin heavy chain IIa antibody
      • Myosin heavy chain skeletal muscle adult 2 antibody
      • Myosin heavy polypeptide 2 skeletal muscle adult antibody
      • Myosin-2 antibody
      • MYPOP antibody
      • skeletal muscle antibody
      • Type IIA myosin heavy chain antibody
      see all

    Anti-MYH2 antibody [EPR5280] 图像

    • All lanes : Anti-MYH2 antibody [EPR5280] (ab124937) at 1/10000 dilution

      Lane 1 : Mouse muscle lysate
      Lane 2 : Rat muscle lysate

      Lysates/proteins at 10 µg per lane.

      HRP labelled Goat anti Rabbit IgG at 1/2000 dilution

      Predicted band size : 223 kDa
      Observed band size : 220 kDa (why is the actual band size different from the predicted?)
    • Anti-MYH2 antibody [EPR5280] (ab124937) at 1/10000 dilution + Human trachea lysate at 10 µg

      HRP labelled Goat anti Rabbit IgG at 1/2000 dilution

      Predicted band size : 223 kDa
      Observed band size : 220 kDa (why is the actual band size different from the predicted?)
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-MYH2 antibody [EPR5280] (ab124937)参考文献

    ab124937 has not yet been referenced specifically in any publications.

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