概述

  • 产品名称Anti-MYH抗体
    参阅全部 MYH 一抗
  • 描述
    山羊多克隆抗体to MYH
  • 特异性This antibody is expected to recognise all reported isoforms (NP_036354.1; NP_001041636.1; NP_001041637.1; NP_001041638.1; NP_001041639.1).
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    C-HISTDAHSLNSAAQ

    , corresponding to C terminal amino acids 533-546 of Human MYH

  • 阳性对照
    • Human Bone Marrow lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, 5mg/ml Tris, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab58572 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: antibody detection limit dilution 1/16000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 61 kDa (predicted molecular weight: 61 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
    • 疾病相关Defects in MUTYH are a cause of familial adenomatous polyposis type 2 (FAP2) [MIM:608456]. A condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma.
      Defects in MUTYH are a cause of gastric cancer (GASC) [MIM:613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
    • 序列相似性Belongs to the Nth/MutY family.
      Contains 1 nudix hydrolase domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • A/G specific adenine DNA glycosylase antibody
      • A/G-specific adenine DNA glycosylase antibody
      • Adenine DNA glycosylase antibody
      • CYP2C antibody
      • hMYH antibody
      • MGC4416 antibody
      • MutY (E. coli) homolog antibody
      • MutY homolog (E. coli) antibody
      • MutY homolog antibody
      • MutY, E. coli, homolog of antibody
      • Mutyh antibody
      • MUTYH_HUMAN antibody
      • MYH antibody
      • rMYH antibody
      see all

    Anti-MYH antibody 图像

    • Anti-MYH antibody (ab58572) at 0.1 µg/ml + Human Bone Marrow lysate at 35 µg

      Predicted band size : 61 kDa
      Observed band size : 61 kDa

    Anti-MYH antibody (ab58572)参考文献

    ab58572 has not yet been referenced specifically in any publications.

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