概述

性能

应用

Our Abpromise guarantee covers the use of ab82842 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明ELISA: Use at an assay dependent dilution.
    Antibody specificity was verified by direct ELISA against the 3 immunogen peptides. A minimum titer of 1/17000 is determined for one of the three peptides.
    WB: 1/1000. Detects a band of approximately 41 kDa (predicted molecular weight: 41 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
    • 组织特异性Skeletal muscle.
    • 疾病相关Defects in MYF6 may be a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
    • 序列相似性Contains 1 basic helix-loop-helix (bHLH) domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • bHLHc4 antibody
      • Class C basic helix-loop-helix protein 4 antibody
      • CNM3 antibody
      • HERCULIN antibody
      • MRF4 antibody
      • Muscle-regulatory factor 4 antibody
      • Muscle-specific regulatory factor 4 antibody
      • Myf-6 antibody
      • Myf6 antibody
      • MYF6_HUMAN antibody
      • myogenic factor 6 (herculin) antibody
      • Myogenic factor 6 antibody
      see all

    Anti-MYF6 antibody 图像

    • All lanes : Anti-MYF6 antibody (ab82842) at 1/1000 dilution

      Lane 1 : uninduced culture of E.coli (one shot Top10 competent cells)
      Lane 2 : induced culture of E.coli (one shot Top10 competent cells)

      Secondary
      anti-Rabbit IgG HRP at 1/1000 dilution

      Predicted band size : 41 kDa
      Observed band size : 41 kDa
      Additional bands at : 60 kDa,95 kDa. We are unsure as to the identity of these extra bands.

    Anti-MYF6 antibody (ab82842)参考文献

    ab82842 has not yet been referenced specifically in any publications.

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