Anti-Myeloperoxidase抗体[EPR4792] (ab109116)


  • 产品名称Anti-Myeloperoxidase抗体[EPR4792]
    参阅全部 Myeloperoxidase 一抗
  • 描述
    兔单克隆抗体[EPR4792] to Myeloperoxidase
  • 特异性ab109116 recognizes Myeloperoxidase (85-90 kDa) and its light chain (15 kDa).
  • 经测试应用适用于: ICC/IF, WB, IHC-P, ICCmore details
    不适用于: Flow Cyt or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide, corresponding to residues in Human Myeloperoxidase.

  • 阳性对照
    • WB: HL-60 cell lysate IHC-P: Human colon, lung and spleen tissues
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.


Our Abpromise guarantee covers the use of ab109116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration. PubMed: 24691127
WB 1/1000 - 1/10000. Predicted molecular weight: 84 kDa.
IHC-P 1/250 - 1/500. Antigen retrieval is recommended.
ICC 1/250 - 1/500.
  • 应用说明Is unsuitable for Flow Cyt or IP.
  • 靶标

    • 功能Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
    • 疾病相关Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
    • 序列相似性Belongs to the peroxidase family. XPO subfamily.
    • 细胞定位Lysosome.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 84 kDa myeloperoxidase antibody
      • 89 kDa myeloperoxidase antibody
      • EC antibody
      • EC1.11.2.2 antibody
      • fj80f04 antibody
      • MPO antibody
      • mpx antibody
      • myeloid-specific peroxidase antibody
      • Myeloperoxidase antibody
      • Myeloperoxidase heavy chain antibody
      • Myeloperoxidase light chain antibody
      • PERM_HUMAN antibody
      • wu:fj80f04 antibody
      see all

    Anti-Myeloperoxidase antibody [EPR4792] 图像

    • Anti-Myeloperoxidase antibody [EPR4792] (ab109116) at 1/1000 dilution + HL-60 cell lysate at 10 µg

      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 84 kDa
      Observed band size : 85-90 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 15 kDa (possible cleavage fragment).
    • ab109116, at a 1/250 dilution, staining Myeloperoxidase in paraffin embedded Human colon tissue by Immunohistochemistry.
    • ab109116, at a 1/250 dilution, staining Myeloperoxidase in paraffin embedded Human lung tissue by Immunohistochemistry.
    • ab109116, at a 1/250 dilution, staining Myeloperoxidase in paraffin embedded Human spleen tissue by Immunohistochemistry.
    • ab109116 showing positive staining in Normal liver tissue.

    • ab109116 showing positive staining in Bone marrow tissue.

    • ab109116 showing negative staining in Skeletal muscle tissue.

    Anti-Myeloperoxidase antibody [EPR4792] (ab109116)参考文献

    This product has been referenced in:
    • Baek JH  et al. Extracellular Hb enhances cardiac toxicity in endotoxemic guinea pigs: protective role of haptoglobin. Toxins (Basel) 6:1244-59 (2014). WB, ICC/IF ; Guinea pig . Read more (PubMed: 24691127) »

    See 1 Publication for this product

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