Anti-Myeloperoxidase抗体[8F4] (ab16886)

概述

  • 产品名称
    Anti-Myeloperoxidase抗体[8F4]
    参阅全部 Myeloperoxidase 一抗
  • 描述
    小鼠单克隆抗体[8F4] to Myeloperoxidase
  • 经测试应用
    适用于: IHC-Fr, Flow Cytmore details
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    Purified mouse Myeloperoxidase from WEHI-3 cells.

  • 阳性对照
    • Neutrophils isolated from digested infarcts

性能

应用

Our Abpromise guarantee covers the use of ab16886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr 1/10.
Flow Cyt 1/10. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 功能
    Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
  • 疾病相关
    Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
  • 序列相似性
    Belongs to the peroxidase family. XPO subfamily.
  • 细胞定位
    Lysosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 84 kDa myeloperoxidase antibody
    • 89 kDa myeloperoxidase antibody
    • EC 1.11.1.7 antibody
    • EC1.11.2.2 antibody
    • fj80f04 antibody
    • MPO antibody
    • mpx antibody
    • myeloid-specific peroxidase antibody
    • Myeloperoxidase antibody
    • Myeloperoxidase heavy chain antibody
    • Myeloperoxidase light chain antibody
    • PERM_HUMAN antibody
    • wu:fj80f04 antibody
    see all

图片

  • Detection of MPO in Wehi3BD+ cells. Red, black and blue line represent the isotype control, cells only and ab16886 at 10 μg/ml, respectively.

文献

This product has been referenced in:
  • Lu SM  et al. HIV-1 Tat-Induced Microgliosis and Synaptic Damage via Interactions between Peripheral and Central Myeloid Cells. PLoS One 6:e23915 (2011). IHC-FoFr ; Mouse . Read more (PubMed: 21912650) »
  • Salguero Palacios R  et al. Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice. Lab Invest 88:1192-203 (2008). IHC-Fr ; Mouse . Read more (PubMed: 18794850) »

See all 2 Publications for this product

客户评价及客户问答

Abcam has not validated the combination of species/application used in this Abreview.
Application
Western blot
Sample
Rat Cell lysate - whole cell (Rat Neutrophils and Human MPO)
Loading amount
6 µg
Specification
Rat Neutrophils and Human MPO
Gel Running Conditions
Reduced Denaturing (7.5)
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5.0% · Temperature: 23°C
Username

Mrs. Donna Flanagan

Verified customer

提交于 Mar 13 2009

As far as we know, the epitope has not been mapped. Please contact us again if you have any additional questions.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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