Anti-Myeloperoxidase抗体[2D4] (FITC) (ab90812)

概述

  • 产品名称
    Anti-Myeloperoxidase抗体[2D4] (FITC)
    参阅全部 Myeloperoxidase 一抗
  • 描述
    小鼠单克隆抗体[2D4] to Myeloperoxidase (FITC)
  • 偶联物
    FITC. Ex: 493nm, Em: 528nm
  • 经测试应用
    适用于: IHC-Fr, Flow Cyt, ICC/IFmore details
    不适用于: IHC-P or WB
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    Purified Rat Myeloperoxidase

性能

应用

Our Abpromise guarantee covers the use of ab90812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr 1/50.
Flow Cyt 1/50. ab91356-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
ICC/IF Use at an assay dependent concentration.
  • 应用说明
    Is unsuitable for IHC-P or WB.
  • 靶标

    • 功能
      Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
    • 疾病相关
      Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
    • 序列相似性
      Belongs to the peroxidase family. XPO subfamily.
    • 细胞定位
      Lysosome.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 84 kDa myeloperoxidase antibody
      • 89 kDa myeloperoxidase antibody
      • EC 1.11.1.7 antibody
      • EC1.11.2.2 antibody
      • fj80f04 antibody
      • MPO antibody
      • mpx antibody
      • myeloid-specific peroxidase antibody
      • Myeloperoxidase antibody
      • Myeloperoxidase heavy chain antibody
      • Myeloperoxidase light chain antibody
      • PERM_HUMAN antibody
      • wu:fj80f04 antibody
      see all

    图片

    • Detection of MPO in Wehi3BD+ cells. Red, black and blue line represent the isotype control, cells only and ab90812 at 20 μg/ml, respectively.

    • Immunohistochemistry (Frozen sections) analysis of mouse stomach tissue labeling Myeloperoxidase with ab90812 (green). 8 µm sections were fixed in 4% paraformaldehyde for 10 min, washed in PBS twice, and then blocked with 20% donkey serum in PBS. β-gal (red), and DAPI (blue). 

    文献

    This product has been referenced in:
    • El-Zaatari M  et al. Tryptophan catabolism restricts IFN-?-expressing neutrophils and Clostridium difficile immunopathology. J Immunol 193:807-16 (2014). Mouse . Read more (PubMed: 24935925) »
    • El-Zaatari M  et al. Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PLoS One 8:e58935 (2013). IHC-Fr ; Mouse . Read more (PubMed: 23520544) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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