- 数据表
- 具体的参考文献 (1)
- 实验方案
概述
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产品名称Anti-Myelin PLP抗体
参阅全部 Myelin PLP 一抗 -
描述兔多克隆抗体to Myelin PLP
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宿主Rabbit
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特异性ab28488 recognises PLP.
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经测试应用适用于: WB, ICCmore details
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种属反应性与反应: Mouse
预测可用于: Rat
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免疫原
Synthetic peptide: KL MGRGTK, corresponding to C terminal amino acids 269-276 of Mouse Myelin PLP
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阳性对照
- Adult mouse brain
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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存储溶液Preservative: 0.05% Sodium Azide
Constituents: Whole serum -
纯度Whole antiserum
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab28488 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/1000. Predicted molecular weight: 26,30 kDa. | |
| ICC | 1/1000. |
靶标
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功能This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
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疾病相关Defects in PLP1 are the cause of leukodystrophy hypomyelinating type 1 (HLD1) [MIM:312080]; also known as Pelizaeus-Merzbacher disease. HLD1 is an X-linked recessive dysmyelinating disorder of the central nervous system in which myelin is not formed properly. It is characterized clinically by nystagmus, spastic quadriplegia, ataxia, and developmental delay.
Defects in PLP1 are the cause of spastic paraplegia X-linked type 2 (SPG2) [MIM:312920]. SPG2 is characterized by spastic gait and hyperreflexia. In some patients, complicating features include nystagmus, dysarthria, sensory disturbance, mental retardation, optic atrophy. -
序列相似性Belongs to the myelin proteolipid protein family.
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细胞定位Membrane.
- Information by UniProt
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数据库链接
- Entrez Gene: 18823 Mouse
- Entrez Gene: 24943 Rat
- SwissProt: P60202 Mouse
- SwissProt: P60203 Rat
- Unigene: 1268 Mouse
- Unigene: 4550 Rat
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别名
- HLD1 antibody
- Lipophilin antibody
- Major myelin proteolipid protein antibody
see all
文献
This product has been referenced in:
- Paap RH et al. FoxO6 affects Plxna4-mediated neuronal migration during mouse cortical development. Proc Natl Acad Sci U S A : (2016). Read more (PubMed: 27791111) »
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"