Anti-Myelin PLP抗体(ab28488)

概述

• 产品名称
  Anti-Myelin PLP抗体
  参阅全部 Myelin PLP 一抗
• 描述
  兔多克隆抗体to Myelin PLP
• 特异性
  ab28488 recognises PLP.
• 经测试应用
  适用于: WB, ICCmore details
• 种属反应性
  与反应: Mouse
  预测可用于: Rat
• 免疫原

  Synthetic peptide: KL MGRGTK, corresponding to C terminal amino acids 269-276 of Mouse Myelin PLP

  Run BLAST with Run BLAST with
• 阳性对照
  • Adult mouse brain

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• 存储溶液
  Preservative: 0.05% Sodium Azide
  Constituents: Whole serum
• 纯度
  Whole antiserum
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Neuroscience
  • Cell Adhesion Proteins
  • Membrane Proteins

  • Neuroscience
  • Cell Type Marker
  • Glia marker
  • Oligodendrocyte marker

  • Tags & Cell Markers
  • Cell Type Markers
  • Neuroscience Markers
  • Glial

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能
  This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
• 疾病相关
  Defects in PLP1 are the cause of leukodystrophy hypomyelinating type 1 (HLD1) [MIM:312080]; also known as Pelizaeus-Merzbacher disease. HLD1 is an X-linked recessive dysmyelinating disorder of the central nervous system in which myelin is not formed properly. It is characterized clinically by nystagmus, spastic quadriplegia, ataxia, and developmental delay.
  Defects in PLP1 are the cause of spastic paraplegia X-linked type 2 (SPG2) [MIM:312920]. SPG2 is characterized by spastic gait and hyperreflexia. In some patients, complicating features include nystagmus, dysarthria, sensory disturbance, mental retardation, optic atrophy.
• 序列相似性
  Belongs to the myelin proteolipid protein family.
• 细胞定位
  Membrane.

• Target information above from: UniProt accession P60201 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 18823 Mouse
  • Entrez Gene: 24943 Rat
  • SwissProt: P60202 Mouse
  • SwissProt: P60203 Rat
  • Unigene: 1268 Mouse
  • Unigene: 4550 Rat
• 别名
  • HLD1 antibody
  • Lipophilin antibody
  • Major myelin proteolipid protein antibody

  • MMPL antibody
  • Myelin proteolipid protein antibody
  • MYPR_HUMAN antibody
  • PLP 1 antibody
  • PLP antibody
  • PLP/DM20 antibody
  • PLP1 antibody
  • PMD antibody
  • Proteolipid protein 1 antibody
  • SPG2 antibody

  see all

实验方案

• Western blot protocols
• Immunocytochemistry & immunofluorescence protocols