Anti-Myelin Basic蛋白抗体(ab28541)


  • 产品名称
    Anti-Myelin Basic蛋白抗体
    参阅全部 Myelin Basic Protein 一抗
  • 描述
    兔多克隆抗体to Myelin Basic蛋白
  • 宿主
  • 特异性
    This antibody is specific to myelin basic proteins. It may cross react with other isoforms of myelin basic proteins.
  • 经测试应用
    适用于: WB, IP, Sandwich ELISAmore details
  • 种属反应性
    与反应: Cow, Pig
    预测可用于: Mammal
  • 免疫原

    Full length myelin basic protein (Cow).

  • 阳性对照
    • Bovine brain extract.



Our Abpromise guarantee covers the use of ab28541 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 20 kDa.
IP Use at an assay dependent dilution.
Sandwich ELISA Use at an assay dependent dilution. To be used as capture antibody. Pair with ab77895 - Rabbit polyclonal to Myelin Basic Protein (HRP)


  • 功能
    The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
  • 组织特异性
    MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.
  • 疾病相关
    Note=The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).
  • 序列相似性
    Belongs to the myelin basic protein family.
  • 发展阶段
    Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16 weeks and its relative proportion declines thereafter.
  • 翻译后修饰
    Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic.
    The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6).
    Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated.
  • 细胞定位
    Myelin membrane. Cytoplasmic side of myelin.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GDB antibody
    • Golli MBP antibody
    • Golli MBP; myelin basic protein antibody
    • Hemopoietic MBP antibody
    • HMBPR antibody
    • HUGO antibody
    • MBP antibody
    • MBP_CAVPO antibody
    • MBP_HUMAN antibody
    • MGC99675 antibody
    • MLD antibody
    • Myelin A1 protein antibody
    • Myelin A1 Protein, basic antibody
    • Myelin basic protein antibody
    • Myelin Deficient antibody
    • Myelin membrane encephalitogenic protein antibody
    • OTTHUMP00000163776 antibody
    • OTTHUMP00000174387 antibody
    • OTTHUMP00000174388 antibody
    • SHI antibody
    • Shiverer antibody
    • SP antibody
    see all


  • Fixed Immobilized Anti-MBP (ab28541): 2 ug/mL, 100 ul/well
    Captured Antigen: Swine MBP , range from 1 to 90 ng/mL
    Detection: anti-MBP HRP (ab77895), 0.25 ug/mL in 1% BSA and PBSt
  • Immobilized Anti-MBP (ab28541): range from 0.125 to 2 µg/ml, 100 µl/well
    Fixed Captured Antigen: Swine MBP, 500 ng/mL
    Detection: anti-MBP HRP (ab77895), 0.25 ug/mL in 1% BSA and PBSt


ab28541 has not yet been referenced specifically in any publications.


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