Anti-Myelin Basic Protein抗体[22] (ab11223)

概述

• 产品名称Anti-Myelin Basic Protein抗体[22]
  参阅全部 Myelin Basic Protein 一抗
• 描述
  小鼠单克隆抗体[22] to Myelin Basic Protein
• 经测试应用适用于: IHC-Fr, IHC-Pmore details
• 种属反应性
  与反应: Human
  
• 免疫原

  Full length protein (Human).

• 表位ab11223 recognises an epitope of myelin basic protein between amino acids 84-89.
• 常规说明This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液Preservative: 0.09% Sodium Azide
  Constituents: Tissue Culture Supernatant
• 纯度Tissue culture supernatant
• 克隆单克隆
• 克隆编号22
• 骨髓瘤Sp2/0
• 同种型IgG2b
• 研究领域
  • Neuroscience
  • Cell Adhesion Proteins
  • Membrane Proteins

  • Neuroscience
  • Cell Type Marker
  • Glia marker
  • Oligodendrocyte marker

  • Tags & Cell Markers
  • Cell Type Markers
  • Neuroscience Markers
  • Glial

相关产品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

应用

靶标

• 功能The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
• 组织特异性MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.
• 疾病相关Note=The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).
• 序列相似性Belongs to the myelin basic protein family.
• 发展阶段Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16 weeks and its relative proportion declines thereafter.
• 翻译后修饰Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic.
  The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6).
  Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated.
• 细胞定位Myelin membrane. Cytoplasmic side of myelin.

• Target information above from: UniProt accession P02686 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 4155 Human
  • Omim: 159430 Human
  • SwissProt: P02686 Human
  • Unigene: 551713 Human
• 别名
  • GDB antibody
  • Golli MBP antibody
  • Golli MBP; myelin basic protein antibody

  • Hemopoietic MBP antibody
  • HMBPR antibody
  • HUGO antibody
  • MBP antibody
  • MBP_CAVPO antibody
  • MBP_HUMAN antibody
  • MGC99675 antibody
  • MLD antibody
  • Myelin A1 protein antibody
  • Myelin A1 Protein, basic antibody
  • Myelin basic protein antibody
  • Myelin Deficient antibody
  • Myelin membrane encephalitogenic protein antibody
  • OTTHUMP00000163776 antibody
  • OTTHUMP00000174387 antibody
  • OTTHUMP00000174388 antibody
  • SHI antibody
  • Shiverer antibody
  • SP antibody

  see all