功能May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation.
组织特异性Down-regulated in gastric cancer tissues.
序列相似性Belongs to the MYCT1 family.
细胞定位Nucleus. Expressed in nuclei of hepatocellular carcinoma cell line Bel7402 cells.