RabMAb

Anti-MYBPC3抗体[EPR3008(2)] (ab108522)

概述

  • 产品名称Anti-MYBPC3抗体[EPR3008(2)]
    参阅全部 MYBPC3 一抗
  • 描述
    兔单克隆抗体[EPR3008(2)] to MYBPC3
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC/IF or IHC-P
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human MYBPC3 aa 100-200. The exact sequence is proprietary.

  • 阳性对照
    • WB: Human heart tissue lysate.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated ‘PUR’ on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 40% Glycerol, 0.05% BSA, 59% PBS
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 克隆编号EPR3008(2)
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab108522 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 141 kDa.
  • 应用说明Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
  • 靶标

    • 功能Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
    • 疾病相关Defects in MYBPC3 are the cause of cardiomyopathy familial hypertrophic type 4 (CMH4) [MIM:115197]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • 序列相似性Belongs to the immunoglobulin superfamily. MyBP family.
      Contains 3 fibronectin type-III domains.
      Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
    • 翻译后修饰Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C protein cardiac muscle isoform antibody
      • C-protein antibody
      • cardiac muscle isoform antibody
      • Cardiac MyBP C antibody
      • Cardiac MyBP-C antibody
      • cardiac-type antibody
      • MYBPC3 antibody
      • myosin binding protein C cardiac antibody
      • Myosin binding protein C cardiac type antibody
      • Myosin-binding protein C antibody
      • MYPC3_HUMAN antibody
      see all

    Anti-MYBPC3 antibody [EPR3008(2)] 图像

    • Anti-MYBPC3 antibody [EPR3008(2)] (ab108522) at 1/5000 dilution (purified) + Human heart tissue lysate at 10 µg

      Secondary
      Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/20000 dilution

      Predicted band size : 141 kDa
      Observed band size : 141 kDa

      Blocking and dilution buffer: 5% NFDM /TBST.

    • Anti-MYBPC3 antibody [EPR3008(2)] (ab108522) at 1/1000 dilution (unpurified) + Human heart tissue lysate at 10 µg

      Predicted band size : 141 kDa

    Anti-MYBPC3 antibody [EPR3008(2)] (ab108522)参考文献

    ab108522 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"