概述

  • 产品名称Anti-MYBPC3抗体
    参阅全部 MYBPC3 一抗
  • 描述
    兔多克隆抗体to MYBPC3
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from internal region of Human MYBPC3.

  • 阳性对照
    • Human heart tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol
    Note: PBS (without Mg2+ and Ca2+)
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab110832 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab110832 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
  • 疾病相关Defects in MYBPC3 are the cause of cardiomyopathy familial hypertrophic type 4 (CMH4) [MIM:115197]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 序列相似性Belongs to the immunoglobulin superfamily. MyBP family.
    Contains 3 fibronectin type-III domains.
    Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
  • 翻译后修饰Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C protein cardiac muscle isoform antibody
    • C-protein antibody
    • cardiac muscle isoform antibody
    • Cardiac MyBP C antibody
    • Cardiac MyBP-C antibody
    • cardiac-type antibody
    • MYBPC3 antibody
    • myosin binding protein C cardiac antibody
    • Myosin binding protein C cardiac type antibody
    • Myosin-binding protein C antibody
    • MYPC3_HUMAN antibody
    see all

Anti-MYBPC3 antibody 图像

  • ab110832 at 1/50 staining MYBPC3 in paraffin-embedded Human Heart tissue, left panel shows staining without peptide right panel shows staining with peptide.

Anti-MYBPC3 antibody (ab110832)参考文献

ab110832 has not yet been referenced specifically in any publications.

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