概述

  • 产品名称Anti-MXI1抗体
    参阅全部 MXI1 一抗
  • 描述
    兔多克隆抗体to MXI1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Chicken, Guinea pig, Cow, Cat, Dog, Saccharomyces cerevisiae
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 216-265 (GPQEMERIRM DSIGSTISSD RSDSEREEIE VDVESTEFSH GEVDNISTTS) of Human MXI1 (NP_569157).

  • 阳性对照
    • SH SYSY cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab90311 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
  • 组织特异性High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
  • 疾病相关Defects in MXI1 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • 序列相似性Contains 1 basic helix-loop-helix (bHLH) domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • bHLHc11 antibody
    • Class C basic helix-loop-helix protein 11 antibody
    • MAD 2 antibody
    • MAD2 antibody
    • MAX dimerization protein 2 antibody
    • MAX interacting protein 1 antibody
    • Max interactor 1 antibody
    • Max related transcription factor antibody
    • MAX-interacting protein 1 antibody
    • MGC43220 antibody
    • MXD 2 antibody
    • MXD2 antibody
    • MXI 1 antibody
    • MXI antibody
    • mxi1 antibody
    • MXI1 protein antibody
    • MXI1_HUMAN antibody
    • Protein MXI1 antibody
    see all

Anti-MXI1 antibody 图像

  • Anti-MXI1 antibody (ab90311) at 1 µg/ml (in 5% skim milk / PBS buffer) + SH SYSY cell lysate at 10 µg

    Secondary
    HRP conjugated anti-rabbit IgG at 1/50000 dilution

    Predicted band size : 33 kDa

Anti-MXI1 antibody (ab90311)参考文献

ab90311 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab90311.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"