概述

  • 产品名称Anti-MXI1抗体
    参阅全部 MXI1 一抗
  • 描述
    兔多克隆抗体to MXI1
  • 特异性ab29740 recognises MAX interacting protein 1 (MXI1)
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide derived from residues 176 - 225 of human MXI1. Note: the amino acid sequence is proprietary).

  • 阳性对照
    • Fetal Brain lysate Human Lung tissue

性能

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应用

Our Abpromise guarantee covers the use of ab28740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
WB Use a concentration of 1 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 33 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
  • 组织特异性High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
  • 疾病相关Defects in MXI1 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • 序列相似性Contains 1 basic helix-loop-helix (bHLH) domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • bHLHc11 antibody
    • Class C basic helix-loop-helix protein 11 antibody
    • MAD 2 antibody
    • MAD2 antibody
    • MAX dimerization protein 2 antibody
    • MAX interacting protein 1 antibody
    • Max interactor 1 antibody
    • Max related transcription factor antibody
    • MAX-interacting protein 1 antibody
    • MGC43220 antibody
    • MXD 2 antibody
    • MXD2 antibody
    • MXI 1 antibody
    • MXI antibody
    • mxi1 antibody
    • MXI1 protein antibody
    • MXI1_HUMAN antibody
    • Protein MXI1 antibody
    see all

Anti-MXI1 antibody 图像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung tissue labelling MXI1 with ab28740 at 4-8µg/ml. Positively labelled cells are (indicated by arrows) are bronchiole epithelial cells. Magnification: X400.

  • Anti-MXI1 antibody (ab28740) at 1 µg/ml + Foetal brain lysate

    Secondary
    HRP conjugated anti-Rabbit IgG diluted 1/50,000 - 1/100,000

    Predicted band size : 33 kDa
    Observed band size : ~37 kDa (why is the actual band size different from the predicted?)

Anti-MXI1 antibody (ab28740)参考文献

ab28740 has not yet been referenced specifically in any publications.

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