概述

  • 产品名称Anti-MVP抗体
    参阅全部 MVP 一抗
  • 描述
    兔多克隆抗体to MVP
  • 特异性This antibody is specific for MVP.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A KLH conjugated synthetic peptide (10-30 aa in length) at the C-term of last 50 aa of human MVP.

  • 阳性对照
    • A375 lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab38309 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 100 kDa (predicted molecular weight: 99 kDa).

靶标

  • 功能Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
  • 组织特异性Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
  • 序列相似性Contains 9 MVP (vault) repeats.
  • 结构域MVP 3 mediates interaction with PTEN.
    MVP 4 mediates interaction with PARP4.
  • 翻译后修饰Phosphorylated on Tyr residues after EGF stimulation.
    Dephosphorylated by PTPN11.
  • 细胞定位Cytoplasm. Nucleus > nuclear pore complex. 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
  • Information by UniProt
  • 数据库链接
  • 别名
    • LRP antibody
    • Lung resistance related protein antibody
    • Lung resistance-related protein antibody
    • Major vault protein antibody
    • Major vault protein, rat, homolog of antibody
    • MVP antibody
    • MVP_HUMAN antibody
    • testicular secretory protein Li 30 antibody
    • VAULT 1 antibody
    • VAULT1 antibody
    see all

Anti-MVP antibody 图像

  • Anti-MVP antibody (ab38309) at 1/100 dilution + A375 lysate

    Predicted band size : 99 kDa
    Observed band size : 100 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 25 kDa,60 kDa,75 kDa. We are unsure as to the identity of these extra bands.

Anti-MVP antibody (ab38309)参考文献

ab38309 has not yet been referenced specifically in any publications.

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