概述

  • 产品名称Anti-MVP抗体
    参阅全部 MVP 一抗
  • 描述
    兔多克隆抗体to MVP
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    QAPQAPGDNHVVPVLR

    conjugated to KLH, corresponding to C terminal amino acids 878-893 of Human MVP (NP_059447.2).

  • 阳性对照
    • Human Testis tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab115928 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
  • 组织特异性Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
  • 序列相似性Contains 9 MVP (vault) repeats.
  • 结构域MVP 3 mediates interaction with PTEN.
    MVP 4 mediates interaction with PARP4.
  • 翻译后修饰Phosphorylated on Tyr residues after EGF stimulation.
    Dephosphorylated by PTPN11.
  • 细胞定位Cytoplasm. Nucleus > nuclear pore complex. 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
  • Information by UniProt
  • 数据库链接
  • 别名
    • LRP antibody
    • Lung resistance related protein antibody
    • Lung resistance-related protein antibody
    • Major vault protein antibody
    • Major vault protein, rat, homolog of antibody
    • MVP antibody
    • MVP_HUMAN antibody
    • testicular secretory protein Li 30 antibody
    • VAULT 1 antibody
    • VAULT1 antibody
    see all

Anti-MVP antibody 图像

  • ab115928, at 10 µg/ml, staining MVP in Formalin-fixed, Paraffin-embedded Human Testis tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-MVP antibody (ab115928)参考文献

ab115928 has not yet been referenced specifically in any publications.

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