Anti-MVK抗体- Aminoterminal end (ab71458)

概述

  • 产品名称Anti-MVK抗体- Aminoterminal end
    参阅全部 MVK 一抗
  • 描述
    兔多克隆抗体to MVK - Aminoterminal end
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide (Human) conjugated to KLH

  • 阳性对照
    • Mouse kidney cytoplasmic lysate

性能

应用

Our Abpromise guarantee covers the use of ab71458 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 42 kDa.

靶标

  • 功能May be a regulatory site in cholesterol biosynthetic pathway.
  • 通路Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
  • 疾病相关Defects in MVK are the cause of mevalonic aciduria (MEVA) [MIM:610377]. It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia.
    Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) [MIM:260920]. HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal.
  • 序列相似性Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
  • 细胞定位Cytoplasm. Peroxisome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ96772 antibody
    • KIME_HUMAN antibody
    • LH receptor mRNA binding protein antibody
    • LRBP antibody
    • Mevalonate kinase 1 antibody
    • Mevalonate kinase antibody
    • Mevalonic aciduria antibody
    • MK antibody
    • mvk antibody
    • MVLK antibody
    • POROK3 antibody
    see all

Anti-MVK antibody - Aminoterminal end 图像

Anti-MVK antibody - Aminoterminal end (ab71458)参考文献

ab71458 has not yet been referenced specifically in any publications.

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