概述

  • 产品名称Anti-MVK抗体
    参阅全部 MVK 一抗
  • 描述
    兔多克隆抗体to MVK
  • 特异性Detects endogenous levels of total MVK protein.
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from an internal region of human MVK

  • 阳性对照
    • Human brain tisue Cos7 cell extract COLO205 cell extract

性能

应用

Our Abpromise guarantee covers the use of ab72588 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).
ELISA 1/10000.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能May be a regulatory site in cholesterol biosynthetic pathway.
  • 通路Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
  • 疾病相关Defects in MVK are the cause of mevalonic aciduria (MEVA) [MIM:610377]. It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia.
    Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) [MIM:260920]. HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal.
  • 序列相似性Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
  • 细胞定位Cytoplasm. Peroxisome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ96772 antibody
    • KIME_HUMAN antibody
    • LH receptor mRNA binding protein antibody
    • LRBP antibody
    • Mevalonate kinase 1 antibody
    • Mevalonate kinase antibody
    • Mevalonic aciduria antibody
    • MK antibody
    • mvk antibody
    • MVLK antibody
    • POROK3 antibody
    see all

Anti-MVK antibody 图像

  • Immunohistochemical analysis of paraffin-embedded human brain tissue using ab72588 at 1/50 dilution. Right panel was also treated with immunising peptide.
  • All lanes : Anti-MVK antibody (ab72588) at 1/500 dilution

    Lane 1 : Cos7 cell extract
    Lane 2 : COLO205 cell extract
    Lane 3 : COLO205 cell extract with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 42 kDa
    Observed band size : 42 kDa
    Additional bands at : 80 kDa. We are unsure as to the identity of these extra bands.

Anti-MVK antibody (ab72588)参考文献

ab72588 has not yet been referenced specifically in any publications.

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