概述

  • 产品名称Anti-MUSK抗体
    参阅全部 MUSK 一抗
  • 描述
    小鼠单克隆抗体to MUSK
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: ISIAEWSKPQ KDNKGYCAQY RGEVCNAVLA KDALVFLNTS YADPEEAQEL LVHTAWNELK VVSPVCRPAA EALLCNHIFQ ECSPGVVPTP IPICREYCLA , corresponding to amino acids 301-400 of Human MUSK

性能

应用

Our Abpromise guarantee covers the use of ab55549 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization.
    • 疾病相关Defects in MUSK is a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (CMS-ACHRD) [MIM:608931]. A post-synaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance. Note=MUSK mutations lead to decreased agrin-dependent AChR aggregation, a critical step in the formation of the neuromuscular junction.
    • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family.
      Contains 1 FZ (frizzled) domain.
      Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 protein kinase domain.
    • 翻译后修饰Ubiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • MDK 4 antibody
      • MDK4 antibody
      • MGC126323 antibody
      • MGC126324 antibody
      • Muscle antibody
      • Muscle skeletal receptor tyrosine kinase antibody
      • Muscle skeletal receptor tyrosine protein kinase antibody
      • Muscle specific kinase receptor antibody
      • Muscle specific tyrosine kinase receptor antibody
      • Muscle specific tyrosine protein kinase receptor antibody
      • Muscle-specific kinase receptor antibody
      • Muscle-specific tyrosine-protein kinase receptor antibody
      • MuSK antibody
      • MUSK_HUMAN antibody
      • Neural fold somite kinase 1 antibody
      • Neural fold somite kinase 2 antibody
      • Neural fold somite kinase 3 antibody
      • Neural fold somite kinase1 antibody
      • Neural fold somite kinase2 antibody
      • Neural fold somite kinase3 antibody
      • Nsk 1 antibody
      • Nsk 2 antibody
      • Nsk 3 antibody
      • Nsk1 antibody
      • Nsk2 antibody
      • Nsk3 antibody
      • Receptor tyrosine kinase MuSK antibody
      • Skeletal muscle receptor tyrosine kinase antibody
      • skeletal receptor tyrosine-protein kinase antibody
      see all

    Anti-MUSK antibody 图像



    • Predicted band size : 97 kDa
      MUSK antibody (ab55549) at 1ug/lane + Jurkat cell lysate at 25ug/lane.

    Anti-MUSK antibody (ab55549)参考文献

    ab55549 has not yet been referenced specifically in any publications.

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