Anti-Muscleblind-like 1抗体[EPR4565] (ab108519)


  • 产品名称Anti-Muscleblind-like 1抗体[EPR4565]
    参阅全部 Muscleblind-like 1 一抗
  • 描述
    兔单克隆抗体[EPR4565] to Muscleblind-like 1
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC,IHC-P or IP
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human Muscleblind-like 1.

  • 阳性对照
    • Jurkat, HeLa, and A673 cell lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab108519 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 42 kDa.
  • 应用说明Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • 靶标

    • 功能Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
    • 组织特异性Highly expressed in cardiac, skeletal muscle and during myoblast differentiation. Weakly expressed in other tissues (at protein level). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    • 疾病相关Plays a role in the pathogenesis of dystrophia myotonica type 1 (DM1) [MIM:160900]. A muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias. Note=In muscle cells from DM1 patients, MBNL1 is sequestered by DMPK RNAs containing CUG triplet repeat expansions. MBNL1 binding is proportional to repeat length consistent with the direct correlation between the length of repeat expansion and disease severity.
    • 序列相似性Belongs to the muscleblind family.
      Contains 4 C3H1-type zinc fingers.
    • 细胞定位Nucleus. Cytoplasm. Cytoplasmic granule. Localized with DDX1, TIAL1 and YBX1 in stress granules upon stress. Localized in the cytoplasm of multinucleated myotubes. Colocalizes with nuclear foci of retained expanded-repeat transcripts in myotubes from patients affected by myotonic dystrophy.
    • Information by UniProt
    • 数据库链接
    • 别名
      • EXP antibody
      • EXP35 antibody
      • EXP40 antibody
      • EXP42 antibody
      • KIAA0428 antibody
      • MBNL antibody
      • MBNL protein antibody
      • MBNL1 antibody
      • MBNL1_HUMAN antibody
      • Muscleblind 41kD isoform antibody
      • Muscleblind like antibody
      • Muscleblind like protein 1 antibody
      • Muscleblind like splicing regulator 1 antibody
      • Muscleblind-like protein 1 antibody
      • Triplet expansion RNA binding protein antibody
      • Triplet-expansion RNA-binding protein antibody
      see all

    Anti-Muscleblind-like 1 antibody [EPR4565] 图像

    • All lanes : Anti-Muscleblind-like 1 antibody [EPR4565] (ab108519) at 1/1000 dilution

      Lane 1 : Jurkat cell lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : A673 cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size : 42 kDa

    Anti-Muscleblind-like 1 antibody [EPR4565] (ab108519)参考文献

    ab108519 has not yet been referenced specifically in any publications.

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