Anti-Munc18-1抗体[EPR4849] (ab109023)

概述

• 产品名称Anti-Munc18-1抗体[EPR4849]
  参阅全部 Munc18-1 一抗
• 描述
  兔单克隆抗体[EPR4849] to Munc18-1
• 经测试应用适用于: WB, IP, ICC/IFmore details
  不适用于: Flow Cyt or IHC-P
• 种属反应性
  与反应: Mouse, Rat, Human
  
• 免疫原

  A synthetic peptide corresponding to residues in Human Munc18.

• 阳性对照
  • SH SY5Y and Human fetal brain lysates; SH SY5Y cells.
• 常规说明

  This product is a recombinant rabbit monoclonal antibody.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• 存储溶液PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• 纯度Tissue culture supernatant
• 克隆单克隆
• 克隆编号EPR4849
• 同种型IgG
• 研究领域
  • Neuroscience
  • Neurotransmission
  • Secretory Vesicles
  • Munc18

  • Neuroscience
  • Cell Type Marker
  • Neuron marker
  • Synapse marker

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Integration of energy metabolism

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Integration of energy

  • Metabolism
  • Types of disease
  • Cancer

应用

靶标

• 功能May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
• 组织特异性Brain and spinal cord. Highly enriched in axons.
• 疾病相关Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
• 序列相似性Belongs to the STXBP/unc-18/SEC1 family.
• 细胞定位Cytoplasm. Membrane.

• Target information above from: UniProt accession P61764 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 6812 Human
  • Entrez Gene: 20910 Mouse
  • Entrez Gene: 25558 Rat
  • Omim: 602926 Human
  • SwissProt: P61764 Human
  • SwissProt: O08599 Mouse
  • SwissProt: P61765 Rat
  • Unigene: 288229 Human

  • Unigene: 278865 Mouse
  • Unigene: 80843 Rat

  see all
• 别名
  • FLJ37475 antibody
  • Munc 18 1 antibody
  • Munc 18a antibody

  • MUNC18 1 antibody
  • N-Sec1 antibody
  • Neuronal SEC1 antibody
  • NSec1 antibody
  • p67 antibody
  • Protein unc-18 homolog 1 antibody
  • Protein unc-18 homolog A antibody
  • Rb sec1 antibody
  • RBSEC1 antibody
  • STXB1_HUMAN antibody
  • STXBP1 antibody
  • Syntaxin binding protein 1 antibody
  • Syntaxin-binding protein 1 antibody
  • Unc 18 homolog antibody
  • Unc 18A antibody
  • Unc-18A antibody
  • Unc18 1 antibody
  • UNC18 antibody
  • Unc18-1 antibody

  see all