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RabMAb

Anti-Munc18-1抗体[EPR4849] (ab109023)

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概述

  • 产品名称
    Anti-Munc18-1抗体[EPR4849]
    参阅全部 Munc18-1 一抗
  • 描述
    兔单克隆抗体[EPR4849] to Munc18-1
  • 宿主
    Rabbit
  • 经测试应用
    适用于: WB, IP, ICC/IFmore details
    不适用于: Flow Cyt or IHC-P
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide within Human Munc18-1 aa 150-250. The exact sequence is proprietary.

  • 阳性对照
    • SH SY5Y and Human fetal brain lysates; SH SY5Y cells.
  • 常规说明

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

性能

应用

Our Abpromise guarantee covers the use of ab109023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 68 kDa.
IP 1/10 - 1/100.
ICC/IF 1/100 - 1/250.
  • 应用说明
    Is unsuitable for Flow Cyt or IHC-P.

    • 靶标

    • 功能
      May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
    • 组织特异性
      Brain and spinal cord. Highly enriched in axons.
    • 疾病相关
      Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
    • 序列相似性
      Belongs to the STXBP/unc-18/SEC1 family.
    • 细胞定位
      Cytoplasm. Membrane.
    • Information by UniProt
    • 数据库链接
      see all
    • 别名
      • FLJ37475 antibody
      • Munc 18 1 antibody
      • Munc 18a antibody
      • MUNC18 1 antibody
      • N-Sec1 antibody
      • Neuronal SEC1 antibody
      • NSec1 antibody
      • p67 antibody
      • Protein unc-18 homolog 1 antibody
      • Protein unc-18 homolog A antibody
      • Rb sec1 antibody
      • RBSEC1 antibody
      • STXB1_HUMAN antibody
      • STXBP1 antibody
      • Syntaxin binding protein 1 antibody
      • Syntaxin-binding protein 1 antibody
      • Unc 18 homolog antibody
      • Unc 18A antibody
      • Unc-18A antibody
      • Unc18 1 antibody
      • UNC18 antibody
      • Unc18-1 antibody
      see all

    图片

    • Western blot - Anti-Munc18-1 antibody [EPR4849] (ab109023)
      Western blot - Anti-Munc18-1 antibody [EPR4849] (ab109023)
      All lanes : Anti-Munc18-1 antibody [EPR4849] (ab109023) at 1/1000 dilution

      Lane 1 : SH SY5Y cell lysate
      Lane 2 : Human fetal brain lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 68 kDa

    • Immunocytochemistry/ Immunofluorescence - Anti-Munc18-1 antibody [EPR4849] (ab109023)
      Immunocytochemistry/ Immunofluorescence - Anti-Munc18-1 antibody [EPR4849] (ab109023)
      ab109023 at 1/100 dilution staining Munc18 in SH SY5Y cells by Immunofluorescence.

    文献

    ab109023 has not yet been referenced specifically in any publications.

    发表研究结果有使用 ab109023？请让我们知道，以便我们可以引用本数据表中的参考文章。

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