Anti-Munc 13抗体[Munc13-71] (ab50566)

概述

  • 产品名称Anti-Munc 13抗体[Munc13-71]
    参阅全部 Munc 13 一抗
  • 描述
    小鼠单克隆抗体[Munc13-71] to Munc 13
  • 特异性ab50566 recognises Munc13-1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Rat
    预测可用于: Human
  • 免疫原

    Synthetic peptide:

    KAKFDGAQEKFNTYVTLK

    conjugated to KLH, corresponding to amino acids 10-27 of Rat Munc 13

  • 阳性对照
    • Cytosolic rat brain S1 fraction

性能

应用

Our Abpromise guarantee covers the use of ab50566 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 193 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 相关性Function: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Tissue specificity: Expressed in pancreatic islet cells (PubMed:12871971). Expressed in melanocytes (PubMed:23999003). Similarity: Belongs to the unc-13 family. Contains 3 C2 domains. Contains 1 MHD1 (MUNC13 homology domain 1) domain. Contains 1 MHD2 (MUNC13 homology domain 2) domain. Contains 1 phorbol-ester/DAG-type zinc finger. Domain: The C2 domains are not involved in calcium-dependent phospholipid binding. The C-terminal region containing both MHD domains and the third C2 domain is required for synaptic vesicle priming activity.
  • 细胞定位Cytoplasm. Cell membrane; Peripheral membrane protein. Cell junction; synapse, presynaptic cell membrane. Note: Localized to the active zone of presynaptic density. Translocated to the plasma membrane as response to phorbol ester binding
  • 数据库链接
  • 别名
    • KIAA1032 antibody
    • Munc13-1 antibody
    • Protein unc-13 homolog A antibody
    • UN13A antibody
    • UN13A_HUMAN antibody
    • Unc 13 homolog A antibody
    • Unc13a (gene name) antibody
    • Unc13a antibody
    • Unc13h1 (gene name) antibody
    see all

Anti-Munc 13 antibody [Munc13-71] (ab50566)参考文献

ab50566 has not yet been referenced specifically in any publications.

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