概述

  • 产品名称Anti-Munc 13-4抗体
    参阅全部 Munc 13-4 一抗
  • 描述
    兔多克隆抗体to Munc 13-4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide, corresponding to a region within the C terminal amino acids 1029-1090 of Human Munc 13-4 (NP_954712)

  • 阳性对照
    • MOLT4 cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab96671 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 123 kDa.

靶标

  • 功能Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
  • 组织特异性Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
  • 疾病相关Defects in UNC13D are the cause of hemophagocytic lymphohistiocytosis familial type 3 (FHL3) [MIM:608898]; also known as HPLH3. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T lymphocytes in lymph nodes, spleen, and other organs is also found.
  • 序列相似性Belongs to the unc-13 family.
    Contains 2 C2 domains.
    Contains 1 MHD1 (MUNC13 homology domain 1) domain.
    Contains 1 MHD2 (MUNC13 homology domain 2) domain.
  • 结构域The MHD1 and MHD2 domains mediate localization on recycling endosomes and lysosome.
  • 细胞定位Cytoplasm. Membrane. Late endosome. Recycling endosome. Lysosome. Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles.
  • Information by UniProt
  • 数据库链接
  • 形式There are 3 isoforms produced by alternative splicing.
  • 别名
    • FHL 3 antibody
    • FHL3 antibody
    • FLJ00067 antibody
    • HLH 3 antibody
    • HLH3 antibody
    • HPLH 3 antibody
    • HPLH3 antibody
    • Jinx antibody
    • Munc13 4 antibody
    • Munc13-4 antibody
    • Protein unc 13 homolog D antibody
    • Protein unc-13 homolog D antibody
    • UN13D_HUMAN antibody
    • Unc 13 homolog D antibody
    • UNC 13D antibody
    • Unc-13 homolog D (C. elegans) antibody
    • Unc13 homolog D (C elegans) antibody
    • Unc13 homolog D antibody
    • UNC13, C. elegans, homolog of, D antibody
    • UNC13D antibody
    • Unc13h4 antibody
    see all

Anti-Munc 13-4 antibody 图像

  • Anti-Munc 13-4 antibody (ab96671) at 1/500 dilution + Molt-4 whole cell lysate at 30 µg

    Predicted band size : 123 kDa

Anti-Munc 13-4 antibody (ab96671)参考文献

ab96671 has not yet been referenced specifically in any publications.

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