功能Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.
序列相似性Belongs to the MUM1 family. Contains 1 PWWP domain.
结构域The PWWP domain mediates the interaction with nucleosomes.
翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
细胞定位Nucleus. Recuited to DNA damage sites via its interaction with the BRCT domain of TP53BP1.