概述

性能

应用

Our Abpromise guarantee covers the use of ab101168 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 52 kDa.
IP Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.
  • 组织特异性Lymphoid cells.
  • 疾病相关Defects in IRF4 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IRF4 is found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus.
  • 序列相似性Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Interferon regulatory factor 4 antibody
    • IRF 4 antibody
    • IRF-4 antibody
    • Irf4 antibody
    • IRF4_HUMAN antibody
    • LSIRF antibody
    • Lymphocyte specific interferon regulatory factor antibody
    • Lymphocyte specific IRF antibody
    • Lymphocyte-specific interferon regulatory factor antibody
    • Multiple myeloma oncogene 1 antibody
    • MUM 1 antibody
    • MUM1 antibody
    • NF EM5 antibody
    • NF-EM5 antibody
    • NFEM5 antibody
    • PU.1 interaction partner antibody
    • Sfpi1/PU.1 interaction partner antibody
    • Transcriptional activator PIP antibody
    see all

Anti-MUM1 antibody (ab101168)参考文献

ab101168 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab101168.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"