概述

  • 产品名称Anti-MUC5B抗体[6F10-E4]
    参阅全部 MUC5B 一抗
  • 描述
    小鼠单克隆抗体[6F10-E4] to MUC5B
  • 特异性Non glycosylated domain of mucin MUC5B.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide

    RNREQVGKF

    from 4 of the cysteine domains of the tandem repeat region of Human MUC5B conjugated to KLH.

  • 常规说明


    Detection of respiratory and salivary mucins in clinical and experimental material.

性能

应用

Our Abpromise guarantee covers the use of ab105460 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 596 kDa. PubMed: 14678646

Please consult PubMed ID 14678646 for the recommended electrophoresis conditions.

靶标

  • 功能Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.
  • 组织特异性Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas.
  • 序列相似性Contains 1 CTCK (C-terminal cystine knot-like) domain.
    Contains 3 HAT repeats.
    Contains 3 TIL (trypsin inhibitory-like) domains.
    Contains 3 VWFC domains.
    Contains 4 VWFD domains.
  • 结构域The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.
  • 翻译后修饰Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc(2)Hex(1)HexNac1-ol.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2300002I04Rik antibody
    • A130042M24 antibody
    • AV085033 antibody
    • Cervical mucin antibody
    • Cervical mucin MUC5B antibody
    • High molecular weight salivary mucin MG1 antibody
    • MG1 antibody
    • MUC-5B antibody
    • MUC5 antibody
    • MUC5B antibody
    • MUC5B_HUMAN antibody
    • MUC9 antibody
    • Mucin 5 subtype B, tracheobronchial antibody
    • Mucin 5B antibody
    • Mucin 5B oligomeric mucus/gel forming antibody
    • Mucin-5 subtype B antibody
    • Mucin-5B antibody
    • Sublingual gland mucin antibody
    • tracheobronchial antibody
    see all

Anti-MUC5B antibody [6F10-E4] (ab105460)参考文献

This product has been referenced in:
  • Rousseau K  et al. New monoclonal antibodies to non-glycosylated domains of the secreted mucins MUC5B and MUC7. Hybrid Hybridomics 22:293-9 (2003). WB, ELISA ; Human . Read more (PubMed: 14678646) »

See 1 Publication for this product

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I have been searching the antibodies as per your requirements. We have different anti Mucin 5AC antibodies however I am not sure which would better suits you because is not very clear from the immunogen.
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