Anti-MUC17抗体(ab122184)
Key features and details
- Rabbit polyclonal to MUC17
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-MUC17抗体 -
描述
兔多克隆抗体to MUC17 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
antigen sequence, corresponding to amino acids 4122-4262 of Human MUC17.
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阳性对照
- Human small intestine tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab122184于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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IHC-P
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Probably plays a role in maintaining homeostasis on mucosal surfaces. -
组织特异性
Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers. -
序列相似性
Contains 1 EGF-like domain.
Contains 1 SEA domain. -
翻译后修饰
Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated. -
细胞定位
Cell membrane and Secreted. Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 140453 Human
- SwissProt: Q685J3 Human
- Unigene: 271819 Human
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别名
- Membrane mucin MUC17 antibody
- MUC-17 antibody
- MUC-3 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab122184 被引用在 4 文献中.
- Sun WW et al. Nanoarchitecture and dynamics of the mouse enteric glycocalyx examined by freeze-etching electron tomography and intravital microscopy. Commun Biol 3:5 (2020). PubMed: 31925335
- Al Amri WS et al. Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer. Mol Cancer Ther 19:945-955 (2020). PubMed: 31879365
- Li W et al. The Prognosis Value of PIWIL1 and PIWIL2 Expression in Pancreatic Cancer. J Clin Med 8:N/A (2019). PubMed: 31443431
- Yang CW et al. Genetic variations of MUC17 are associated with endometriosis development and related infertility. BMC Med Genet 16:60 (2015). IHC . PubMed: 26285705