概述

  • 产品名称
    Anti-MUC17抗体
  • 描述
    兔多克隆抗体to MUC17
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 4122-4262 of Human MUC17.

  • 阳性对照
    • Human small intestine tissue.

性能

应用

Our Abpromise guarantee covers the use of ab122184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Probably plays a role in maintaining homeostasis on mucosal surfaces.
  • 组织特异性
    Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers.
  • 序列相似性
    Contains 1 EGF-like domain.
    Contains 1 SEA domain.
  • 翻译后修饰
    Probably cleaved within the SEA domain.
    N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.
  • 细胞定位
    Cell membrane and Secreted. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Membrane mucin MUC17 antibody
    • MUC-17 antibody
    • MUC-3 antibody
    • MUC17 antibody
    • MUC17_HUMAN antibody
    • Mucin 17, cell surface associated antibody
    • Mucin-17 antibody
    • Secreted mucin MUC17 antibody
    • Small intestinal mucin MUC3 antibody
    • Small intestinal mucin-3 antibody
    see all

图片

  • ab122184 at 1/20 dilution staining MUC17 in Paraffin-embedded Human Small intestine tissue by Immunohistochemistry.

文献

This product has been referenced in:
  • Yang CW  et al. Genetic variations of MUC17 are associated with endometriosis development and related infertility. BMC Med Genet 16:60 (2015). IHC . Read more (PubMed: 26285705) »

See 1 Publication for this product

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