Anti-MUC16抗体[2F1] (ab63903)

概述

  • 产品名称Anti-MUC16抗体[2F1]
    参阅全部 MUC16 一抗
  • 描述
    小鼠单克隆抗体[2F1] to MUC16
  • 特异性ab63903 recognizes B-domain (M11-like) in the protein core of the human CA125 ovarian cancer antigen.
  • 经测试应用适用于: ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Affinity purified human CA125 antigen

性能

应用

Our Abpromise guarantee covers the use of ab63903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
  • 应用说明ELISA: Use at an assay dependent dilution.
    Suitable for use as the detection or conjugate (label) antibody.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
    • 组织特异性Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.
    • 序列相似性Contains 2 ANK repeats.
      Contains 56 SEA domains.
    • 结构域Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail.
    • 翻译后修饰Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.
      Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.
      May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.
      May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
    • 细胞定位Cell membrane. Secreted > extracellular space. May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CA 125 antibody
      • CA-125 antibody
      • CA125 antibody
      • CA125 ovarian cancer antigen antibody
      • Cancer antigen 125 antibody
      • FLJ14303 antibody
      • MUC 16 antibody
      • MUC-16 antibody
      • MUC16 antibody
      • MUC16_HUMAN antibody
      • Mucin 16 antibody
      • Mucin 16 cell surface associated antibody
      • Mucin-16 antibody
      • Mucin16 antibody
      • Ovarian cancer related tumor marker CA125 antibody
      • Ovarian cancer-related tumor marker CA125 antibody
      • Ovarian carcinoma antigen CA125 antibody
      see all

    Anti-MUC16 antibody [2F1] (ab63903)参考文献

    ab63903 has not yet been referenced specifically in any publications.

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