Anti-MTMR2抗体(ab96583)

概述

  • 产品名称Anti-MTMR2抗体
    参阅全部 MTMR2 一抗
  • 描述
    兔多克隆抗体to MTMR2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Cow, Zebrafish
  • 免疫原

    Recombinant fragment, corresponding to a sequence within amino acids 221-497 of Human MTMR2 (AAH52990).

  • 阳性对照
    • HeLa and Raji cell lysates; HepG2 whole cell lysates; CL1-0 xenograft tissue.

性能

应用

Our Abpromise guarantee covers the use of ab96583 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 73 kDa.
IHC-P 1/100 - 1/500.

靶标

  • 功能Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate.
  • 疾病相关Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1) [MIM:601382]. CMT4B1 is a recessive, severe form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.
  • 序列相似性Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
    Contains 1 GRAM domain.
    Contains 1 myotubularin phosphatase domain.
  • 结构域The coiled-coil domain mediates interaction with SBF2.
  • 细胞定位Cytoplasm. Membrane. Partly associated with membranes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CMT4B antibody
    • CMT4B1 antibody
    • KIAA1073 antibody
    • MTMR2 antibody
    • MTMR2_HUMAN antibody
    • Myotubularin related protein 2 antibody
    • Myotubularin-related protein 2 antibody
    • OTTHUMP00000204445 antibody
    • OTTHUMP00000204446 antibody
    • OTTHUMP00000204447 antibody
    • OTTHUMP00000204448 antibody
    • Phosphatidylinositol 3 phosphate phosphatase antibody
    • Phosphatidylinositol 3,5 bisphosphate 3 phosphatase antibody
    see all

Anti-MTMR2 antibody 图像

  • Anti-MTMR2 antibody (ab96583) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 73 kDa
  • ab96583 at 1/100 dilution staining MTMR2 in CL1-0 xenograft by Immunohistochemistry, Paraffin-embedded tissue.

Anti-MTMR2 antibody (ab96583)参考文献

ab96583 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us and for your interest in our products. I am sorry to confirm that as far as we are aware, ab96583 MTMR2 antibody has never been tested in mouse. All tested and guaranteed applications and species are specified on our data...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"