Anti-MTMR14抗体(ab102575)
Key features and details
- Rabbit polyclonal to MTMR14
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-MTMR14抗体
参阅全部 MTMR14 一抗 -
描述
兔多克隆抗体to MTMR14 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 264 and 415 of Human MTMR14 (AAH01674; UniProt ID: Q8NCE2 isoform 3).
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阳性对照
- WB: 293T, A431, Jurkat and Raji cell lysates IHC-P: MCF7 xenograft
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab102575于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 72 kDa.
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IHC-P |
1/100 - 1/500. Antigen retrieval using heat mediated 10mM Citrate buffer or Tris-EDTA buffer (pH 8.0) is recommended.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 72 kDa. |
IHC-P
1/100 - 1/500. Antigen retrieval using heat mediated 10mM Citrate buffer or Tris-EDTA buffer (pH 8.0) is recommended. |
靶标
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功能
Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. -
组织特异性
Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas. -
疾病相关
Defects in MTMR14 may be a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. -
序列相似性
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. -
细胞定位
Cytoplasm. Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 64419 Human
- Entrez Gene: 97287 Mouse
- Entrez Gene: 312634 Rat
- Omim: 611089 Human
- SwissProt: Q8NCE2 Human
- SwissProt: Q8VEL2 Mouse
- Unigene: 475382 Human
- Unigene: 197816 Mouse
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别名
- C3orf29 antibody
- Egg derived tyrosine phosphatase homolog antibody
- FLJ11546 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab102575 被引用在 4 文献中.
- Kong LY et al. Myotubularin-Related Protein14 Prevents Neointima Formation and Vascular Smooth Muscle Cell Proliferation by Inhibiting Polo-Like Kinase1. J Am Heart Assoc 11:e026174 (2022). PubMed: 36314496
- Kovács T et al. A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging. Sci Rep 12:21817 (2022). PubMed: 36528685
- Wen N et al. Deficiency of MTMR14 impairs male fertility in Mus musculus. PLoS One 13:e0206224 (2018). PubMed: 30412589
- Kovács T et al. The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Sci Rep 7:42014 (2017). IHC . PubMed: 28205624