概述

  • 产品名称Anti-MTMR14抗体
    参阅全部 MTMR14 一抗
  • 描述
    兔多克隆抗体to MTMR14
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 395-444 (NFLKHITSEE FSALKTQRRK SLPARDGGFT LEDICMLRRK DRGSTTSLGS) of Human MTMR14 (NP_001070993).

  • 阳性对照
    • Human fetal heart lysate

性能

应用

Our Abpromise guarantee covers the use of ab102085 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 72 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
  • 组织特异性Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas.
  • 疾病相关Defects in MTMR14 may be a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
  • 序列相似性Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
  • 细胞定位Cytoplasm. Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C3orf29 antibody
    • Egg derived tyrosine phosphatase homolog antibody
    • FLJ11546 antibody
    • FLJ22405 antibody
    • FLJ46453 antibody
    • FLJ90311 antibody
    • HCV NS5A transactivated protein 4 splice variant A binding protein 1 antibody
    • HCV NS5A-transactivated protein 4 splice variant A-binding protein 1 antibody
    • hEDTP antibody
    • hJumpy antibody
    • jumpy antibody
    • MTMR 14 antibody
    • MTMR14 antibody
    • MTMRE_HUMAN antibody
    • Myotubularin related protein 14 antibody
    • Myotubularin-related protein 14 antibody
    • NS5ATP4ABP1 antibody
    see all

Anti-MTMR14 antibody 图像

  • Anti-MTMR14 antibody (ab102085) at 1 µg/ml + Human fetal heart lysate at 10 µg

    Predicted band size : 72 kDa

Anti-MTMR14 antibody (ab102085)参考文献

ab102085 has not yet been referenced specifically in any publications.

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