概述

  • 产品名称Anti-MTHFR抗体
    参阅全部 MTHFR 一抗
  • 描述
    小鼠单克隆抗体to MTHFR
  • 经测试应用适用于: WB, ELISA, IHC-Fr, IHC-FoFrmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant full length protein: MAREAPALWP VSSSCGSEGI AREEHLNPMG LDFLGPRWDF FAALAGRTHP GLFFHPFPHV AEDIPTMGWA HNS, corresponding to amino acids 1-74 of Human MTHFR

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab55530 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Can be blocked with Recombinant MTHFR protein (ab152003).
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
ELISA Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration. PubMed: 23525608
IHC-FoFr Use at an assay dependent concentration. PubMed: 22419888

靶标

  • 功能Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
  • 通路One-carbon metabolism; tetrahydrofolate interconversion.
  • 疾病相关Defects in MTHFR are the cause of methylenetetrahydrofolate reductase deficiency (MTHFRD) [MIM:236250]. MTHFRD is autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia [MIM:603174], developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders.
    Defects in MTHFR may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
    Defects in MTHFR may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly.
  • 序列相似性Belongs to the methylenetetrahydrofolate reductase family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 5 10 methylenetetrahydrofolate reductase (NADPH) antibody
    • 5 10 methylenetetrahydrofolate reductase antibody
    • Methylenetetrahydrofolate reductase (NAD(P)H) antibody
    • Methylenetetrahydrofolate reductase antibody
    • Methylenetetrahydrofolate reductase intermediate form antibody
    • MTHFR antibody
    • MTHR_HUMAN antibody
    see all

Anti-MTHFR antibody 图像

  • Western blot against tagged recombinant protein immunogen using ab55530 MTHFR antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa

Anti-MTHFR antibody (ab55530)参考文献

This product has been referenced in:
  • Narayanan N  et al. Hyperhomocysteinemia during aortic aneurysm, a plausible role of epigenetics. Int J Physiol Pathophysiol Pharmacol 5:32-42 (2013). IHC-Fr ; Mouse . Read more (PubMed: 23525608) »
  • Pérez-Sepúlveda A  et al. Levels of key enzymes of methionine-homocysteine metabolism in preeclampsia. Biomed Res Int 2013:731962 (2013). WB ; Human . Read more (PubMed: 24024209) »

See all 4 Publications for this product

Product Wall

Thank you for your patience with this request.

The peptide has been added as ab152003.

I hope this information helps. Please contact us with any other questions.

Thank you for your inquiry and your patience with this reply.

I can get the recombinant protein added for you that was used as an immunogen. This will take a few days, but it is available. Once it is added, I will let you know what the catalo...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"