概述

  • 产品名称
  • 描述
    山羊多克隆抗体to MTHFD1
  • 经测试应用
    适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Xenopus laevis, Orangutan
  • 免疫原

    Synthetic peptide:

    RGDLNDCFIPCTPK

    , corresponding to internal sequence amino acids 137-150 of Human MTHFD1 (NP_005947.2)

  • 阳性对照
    • Human Brain (substantia nigra) lysate.

性能

应用

Our Abpromise guarantee covers the use of ab79283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明
    Peptide ELISA: Antibody detection limit dilution 1/1000.
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 102 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 组织特异性
      Ubiquitous.
    • 通路
      One-carbon metabolism; tetrahydrofolate interconversion.
    • 疾病相关
      Defects in MTHFD1 may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Genetic defects in MTHFD1 may affect the risk of spina bifida via the maternal rather than the embryonic genotype.
      Genetic variation in MTHFD1 could be associated with susceptibility to colorectal cancer (CRC) [MIM:114500].
    • 序列相似性
      In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
      In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
    • 结构域
      This trifunctional enzyme consists of two major domains: an N-terminal part containing the methylene-THF dehydrogenase and cyclohydrolase activities and a larger C-terminal part containing formyl-THF synthetase activity.
    • 细胞定位
      Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 5,10 methylenetetrahydrofolate dehydrogenase 5,10 methylenetetrahydrofolate cyclohydrolase,10 formyltetrahydrofolate synthetase antibody
      • C 1 tetrahydrofolate synthase cytoplasmic antibody
      • C1 tetrahydrofolate synthase cytoplasmic antibody
      • C1 THF synthase antibody
      • C1-THF synthase antibody
      • C1TC antibody
      • C1TC_HUMAN antibody
      • Cytoplasmic C 1 tetrahydrofolate synthase antibody
      • Formyltetrahydrofolate synthetase antibody
      • Methenyltetrahydrofolate cyclohydrolase antibody
      • Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase antibody
      • Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase antibody
      • Methylenetetrahydrofolate dehydrogenase antibody
      • MTHFC antibody
      • MTHFD antibody
      • MTHFD1 antibody
      • NADP dependent cyclohydrolase formyltetrahydrofolate synthetase antibody
      • OTTHUMP00000180657 antibody
      see all

    Anti-MTHFD1 antibody 图像

    实验方案

    Anti-MTHFD1 antibody (ab79283)参考文献

    ab79283 has not yet been referenced specifically in any publications.

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