概述

  • 产品名称Anti-MTHFD1抗体
    参阅全部 MTHFD1 一抗
  • 描述
    山羊多克隆抗体to MTHFD1
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Xenopus laevis, Orangutan
  • 免疫原

    Synthetic peptide:

    RGDLNDCFIPCTPK

    , corresponding to internal sequence amino acids 137-150 of Human MTHFD1 (NP_005947.2)

  • 阳性对照
    • Human Brain (substantia nigra) lysate.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab79283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明Peptide ELISA: Antibody detection limit dilution 1/1000.
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 102 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 组织特异性Ubiquitous.
    • 通路One-carbon metabolism; tetrahydrofolate interconversion.
    • 疾病相关Defects in MTHFD1 may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Genetic defects in MTHFD1 may affect the risk of spina bifida via the maternal rather than the embryonic genotype.
      Genetic variation in MTHFD1 could be associated with susceptibility to colorectal cancer (CRC) [MIM:114500].
    • 序列相似性In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
      In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
    • 结构域This trifunctional enzyme consists of two major domains: an N-terminal part containing the methylene-THF dehydrogenase and cyclohydrolase activities and a larger C-terminal part containing formyl-THF synthetase activity.
    • 细胞定位Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 5,10 methylenetetrahydrofolate dehydrogenase 5,10 methylenetetrahydrofolate cyclohydrolase,10 formyltetrahydrofolate synthetase antibody
      • C 1 tetrahydrofolate synthase cytoplasmic antibody
      • C1 tetrahydrofolate synthase cytoplasmic antibody
      • C1 THF synthase antibody
      • C1-THF synthase antibody
      • C1TC antibody
      • C1TC_HUMAN antibody
      • Cytoplasmic C 1 tetrahydrofolate synthase antibody
      • Formyltetrahydrofolate synthetase antibody
      • Methenyltetrahydrofolate cyclohydrolase antibody
      • Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase antibody
      • Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase antibody
      • Methylenetetrahydrofolate dehydrogenase antibody
      • MTHFC antibody
      • MTHFD antibody
      • MTHFD1 antibody
      • NADP dependent cyclohydrolase formyltetrahydrofolate synthetase antibody
      • OTTHUMP00000180657 antibody
      see all

    Anti-MTHFD1 antibody 图像

    Anti-MTHFD1 antibody (ab79283)参考文献

    ab79283 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab79283.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"