概述

  • 产品名称Anti-MTH1抗体
    参阅全部 MTH1 一抗
  • 描述
    小鼠单克隆抗体to MTH1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-180 of Human MTH1

性能

应用

Our Abpromise guarantee covers the use of ab55527 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
    • 组织特异性Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
    • 序列相似性Belongs to the Nudix hydrolase family.
      Contains 1 nudix hydrolase domain.
    • 发展阶段In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.
    • 翻译后修饰The N-terminus is blocked.
    • 细胞定位Cytoplasm. Mitochondrion matrix and Cytoplasm. Mitochondrion matrix. Nucleus. Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 2-hydroxy-dATP diphosphatase antibody
      • 7 8 dihydro 8 oxoguanine triphosphatase antibody
      • 7 antibody
      • 8 oxo 7 8 dihydrodeoxyguanosine triphosphatase antibody
      • 8 oxo 7 8 dihydroguanosine triphosphatase antibody
      • 8 oxo dGTPase antibody
      • 8-dihydro-8-oxoguanine triphosphatase antibody
      • 8-oxo-dGTPase antibody
      • 8ODP_HUMAN antibody
      • MTH 1 antibody
      • MTH1 antibody
      • MutT human homolog 1 antibody
      • Nucleoside diphosphate linked moiety X motif 1 antibody
      • Nucleoside diphosphate linked moiety X type motif 1 antibody
      • Nucleoside diphosphate-linked moiety X motif 1 antibody
      • Nudix (nucleoside diphosphate linked moiety X) type motif 1 antibody
      • Nudix hydrolase 1 antibody
      • Nudix motif 1 antibody
      • Nudix type motif 1 antibody
      • NUDT 1 antibody
      • Nudt1 antibody
      see all

    Anti-MTH1 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab55527 MTH1 antibody at 1ug/ml. Predicted band size of immunogen is 46 kDa

    Anti-MTH1 antibody (ab55527)参考文献

    ab55527 has not yet been referenced specifically in any publications.

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