概述

  • 产品名称Anti-MTH1抗体
    参阅全部 MTH1 一抗
  • 描述
    兔多克隆抗体to MTH1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human MTH1 Isoform p18 (NP_002443.3, amino acids 1-156).

  • 阳性对照
    • Human kidney tissue lysate, MTH1 transfected 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab103615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 18 kDa.

靶标

  • 功能Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
  • 组织特异性Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
  • 序列相似性Belongs to the Nudix hydrolase family.
    Contains 1 nudix hydrolase domain.
  • 发展阶段In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.
  • 翻译后修饰The N-terminus is blocked.
  • 细胞定位Cytoplasm. Mitochondrion matrix and Cytoplasm. Mitochondrion matrix. Nucleus. Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2-hydroxy-dATP diphosphatase antibody
    • 7 8 dihydro 8 oxoguanine triphosphatase antibody
    • 7 antibody
    • 8 oxo 7 8 dihydrodeoxyguanosine triphosphatase antibody
    • 8 oxo 7 8 dihydroguanosine triphosphatase antibody
    • 8 oxo dGTPase antibody
    • 8-dihydro-8-oxoguanine triphosphatase antibody
    • 8-oxo-dGTPase antibody
    • 8ODP_HUMAN antibody
    • MTH 1 antibody
    • MTH1 antibody
    • MutT human homolog 1 antibody
    • Nucleoside diphosphate linked moiety X motif 1 antibody
    • Nucleoside diphosphate linked moiety X type motif 1 antibody
    • Nucleoside diphosphate-linked moiety X motif 1 antibody
    • Nudix (nucleoside diphosphate linked moiety X) type motif 1 antibody
    • Nudix hydrolase 1 antibody
    • Nudix motif 1 antibody
    • Nudix type motif 1 antibody
    • NUDT 1 antibody
    • Nudt1 antibody
    see all

Anti-MTH1 antibody 图像

  • Anti-MTH1 antibody (ab103615) at 5 µg/ml + Human kidney tissue lysate at 50 µg

    Predicted band size : 18 kDa
  • All lanes : Anti-MTH1 antibody (ab103615) at 5 µg/ml

    Lane 1 : MTH1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 18 kDa

Anti-MTH1 antibody (ab103615)参考文献

This product has been referenced in:
  • Yao Y  et al. Screening and identification of potential predictive biomarkers for Down's syndrome from second trimester maternal serum. Expert Rev Proteomics 12:97-107 (2015). WB ; Human . Read more (PubMed: 25434962) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"