概述

  • 产品名称
    Anti-MTCO2抗体[4B12A5]
    参阅全部 MTCO2 一抗
  • 描述
    小鼠单克隆抗体[4B12A5] to MTCO2
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Saccharomyces cerevisiae
  • 免疫原

    Saccharomyces cerevisiae Cytochrome C oxidase subunit II

  • 阳性对照
    • Mitochondria from yeast membrane extract
  • 常规说明

    This antibody clone is manufactured by Abcam.

    Product was previously marketed under the MitoSciences sub-brand.

性能

应用

Our Abpromise guarantee covers the use of ab110271 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 2 µg/ml. Predicted molecular weight: 26 kDa.

靶标

  • 功能
    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
  • 疾病相关
    Defects in MT-CO2 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
  • 序列相似性
    Belongs to the cytochrome c oxidase subunit 2 family.
  • 细胞定位
    Mitochondrion inner membrane.
  • Information by UniProt
  • 数据库链接
    • 别名
      • COII antibody
      • COX2 antibody
      • COX2_HUMAN antibody
      • COXII antibody
      • Cytochrome c oxidase II antibody
      • Cytochrome c oxidase polypeptide II antibody
      • Cytochrome c oxidase subunit 2 antibody
      • MT CO2 antibody
      • MT-CO2 antibody
      • MTCO2 antibody
      see all

    Anti-MTCO2 antibody [4B12A5] 图像

    • Anti-MTCO2 antibody [4B12A5] (ab110271) at 2 µg/ml + Mitochondria from yeast membrane extract at 10 µg

      Predicted band size : 26 kDa

    实验方案

    Anti-MTCO2 antibody [4B12A5] (ab110271)参考文献

    This product has been referenced in:
    • de Taffin de Tilques M  et al. Overexpression of mitochondrial oxodicarboxylate carrier (ODC1) preserves oxidative phosphorylation in a yeast model of Barth syndrome. Dis Model Mech 10:439-450 (2017). WB . Read more (PubMed: 28188263) »
    • Kaniak-Golik A  et al. Activation of Dun1 in response to nuclear DNA instability accounts for the increase in mitochondrial point mutations in Rad27/FEN1 deficient S. cerevisiae. PLoS One 12:e0180153 (2017). WB ; Saccharomyces cerevisiae . Read more (PubMed: 28678842) »

    See all 23 Publications for this product

    Product Wall

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    The immunogens are as follows;

    ab79393; A synthetic peptide corresponding to residues in human Cytochrome C oxidase subunit II
    ab109739; A synthetic peptide corresponding to residues in Human Cytochro...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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