概述

  • 产品名称Anti-MTA2抗体
    参阅全部 MTA2 一抗
  • 描述
    兔多克隆抗体to MTA2
  • 经测试应用适用于: WB, IP, ELISAmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Horse, Cow, Chimpanzee, Rhesus monkey, Orangutan
  • 免疫原

    Synthetic peptide:

    PAPSHPASTNEPIVLED

    , corresponding to amino acids 652-668 of Human MTA2

  • 阳性对照
    • HeLa Cell Lysate.

性能

应用

Our Abpromise guarantee covers the use of ab66051 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 1 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 75 kDa).
IP Use a concentration of 2 - 5 µg/ml.
ELISA Use a concentration of 0.01 - 0.1 µg/ml.

靶标

  • 相关性The p53 tumor suppressor gene integrates numerous signals that control cell life and death. There are several proteins that are involved in the p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and MTA2. The transcriptional activity of p53 is modulated by protein stability and acetylation. MTA2, also termed MTA1L1, was found to be a subunit of nucleosome remodeling and deacetylating (NuRD) complex. MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by MTA2 represses p53 dependent transcriptional activation and modulates p53 mediated cell growth arrest and apoptosis. MTA2 is ubiquitously expressed in human tissues.
  • 细胞定位Nuclear
  • 数据库链接
  • 别名
    • DKFZp686F2281 antibody
    • Mata1l1 antibody
    • Metastasis associated 1 family member 2 antibody
    • Metastasis associated 1 like 1 antibody
    • Metastasis associated gene 1 like 1 antibody
    • Metastasis associated gene family member 2 antibody
    • Metastasis associated protein 2 antibody
    • Metastasis associated protein MTA 2 antibody
    • Metastasis associated protein MTA2 antibody
    • Mmta2 antibody
    • MTA1 L1 protein antibody
    • MTA1L1 antibody
    • p53 target protein in deacetylase complex antibody
    • PID antibody
    see all

Anti-MTA2 antibody 图像

  • All lanes : Anti-MTA2 antibody (ab66051) at 1 µg/ml

    Lane 1 : HeLa whole cell lysate
    Lane 2 : HeLa whole cell lysate with immunising peptide


    Predicted band size : 75 kDa
    Observed band size : 75 kDa
    Additional bands at : 65 kDa. We are unsure as to the identity of these extra bands.

Anti-MTA2 antibody (ab66051)参考文献

ab66051 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"