概述

  • 产品名称
  • 描述
    兔多克隆抗体to MTA1
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Horse, Cow, Dog, Ferret, Rhesus monkey, Gorilla, Orangutan, Elephant
  • 免疫原

    Synthetic peptide corresponding to a region within residues 400 and 450 of human MTA1 (SwissProt entry Q13330).

  • 阳性对照
    • Human stomach adenocarcinoma; human lung non small cell carcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab84136 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Antigen retrieval is not essential but may optimise staining. The use of citrate buffer will enhance staining.

靶标

  • 功能
    May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.
  • 组织特异性
    Widely expressed. High expression in brain, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual.
  • 序列相似性
    Contains 1 BAH domain.
    Contains 1 ELM2 domain.
    Contains 1 GATA-type zinc finger.
    Contains 1 SANT domain.
  • 发展阶段
    Highly expressed in metastatic cells.
  • 结构域
    Isoform Short contains a Leu-Arg-Ile-Leu-Leu motif (ER binding motif).
  • 细胞定位
    Cytoplasm and Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Metastasis associated 1 antibody
    • Metastasis associated gene 1 antibody
    • Metastasis associated gene 1 protein antibody
    • Metastasis associated protein antibody
    • Metastasis associated protein MTA 1 antibody
    • Metastasis associated protein MTA1 antibody
    • Metastasis-associated protein MTA1 antibody
    • MTA 1 antibody
    • MTA1 antibody
    • MTA1_HUMAN antibody
    see all

图片

  • ab84136, at a 1/100 dilution, staining MTA1 in formalin fixed, paraffin embedded human stomach adenocarcinoma tissue by Immunohistochemistry. Detection: DAB staining.
  • ab84136, at a 1/100 dilution, staining MTA1 in formalin fixed, paraffin embedded human lung non small cell carcinoma tissue by Immunohistochemistry. Detection: DAB staining.

文献

This product has been referenced in:
  • Agboola AO  et al. Clinicopathological and molecular significance of Sumolyation marker (ubiquitin conjugating enzyme 9 (UBC9)) expression in breast cancer of black women. Pathol Res Pract N/A:N/A (2013). IHC-P ; Human . Read more (PubMed: 24176171) »

See 1 Publication for this product

客户评价及客户问答

There are currently no Customer reviews or Questions for ab84136.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册