The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 81 kDa).
功能May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.
组织特异性Widely expressed. High expression in brain, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual.
Predicted band size : 81 kDa ab751 at a concentration of 0.5µg/ml staining approximately 80kDa MTA1 in placental lysate (RIPA buffer, 35µg total protein per lane) by Western blot (ECL). ab751 at a concentration of 0.5µg/ml staining approximately 80kDa MTA1 in placental lysate (RIPA buffer, 35µg total protein per lane) by Western blot (ECL).
Anti-MTA1 antibody (ab751)参考文献
This product has been referenced in:
Weng W et al. Metastasis-associated protein 1 promotes tumor invasion by downregulation of E-cadherin. Int J Oncol44:812-8 (2014).
Read more (PubMed: 24424621) »
Caballero R et al. Combinatorial effects of splice variants modulate function of Aiolos. J Cell Sci120:2619-30 (2007).
Read more (PubMed: 17646674) »