概述

  • 产品名称Anti-MST1/MST2抗体
    参阅全部 MST1/MST2 一抗
  • 描述
    兔多克隆抗体to MST1/MST2
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Rabbit, Horse, Guinea pig, Cow, Turkey, Xenopus laevis, Chimpanzee, Zebrafish, Rhesus monkey, Gorilla, Tilapia, Orangutan, Xenopus tropicalis
  • 免疫原

    Synthetic peptide derived from the C terminal region of Human MST2 using the numbering given in Swiss Prot entry Q13188. The epitope is highly conserved with MST1.

  • 阳性对照
    • Colon carcinoma, placenta, stomach adenocarcinoma.

性能

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应用

Our Abpromise guarantee covers the use of ab87322 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Perform antigen retrieval with tris-EDTA buffer pH9.0 before commencing with IHC staining protocol.
    Likely to work with frozen sections.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性The human serine/threonine kinase, mammalian STE20 like kinase (MST), is considerably homologous to the budding yeast kinases, SPS1 and STE20, throughout their kinase domains. When stably expressed in HeLa cells, MST highly sensitizes the cells to death receptor mediated apoptosis by accelerating caspase 3 activation. These findings suggest that MST1 and MST2 play a role in apoptosis both upstream and downstream of caspase activation. MST1 is cleaved and activated by caspases during apoptosis and is capable of inducing apoptotic morphological changes such as chromatin condensation upon overexpression. Mammalian Sterile 20 Like 2 (MST2) is most similar to the previously identified MST1 protein kinase (78% identity, 88% similarity). Northern analysis indicates that MST2 mRNA is expressed at high levels in adult kidney, skeletal and placental tissues and at very low levels in adult heart, lung, liver and brain tissues. An in vitro kinase assay indicates that MST2 can phosphorylate an exogenous substrate, as well as itself, and phospho amino acid analysis indicates that it is a serine/threonine protein kinase.
    • 细胞定位Cytoplasm. Nucleus. Note: The caspase cleaved form cycles between the nucleus and cytoplasm.
    • 数据库链接
    • 别名
      • DKFZp686A2068 antibody
      • FLJ90748 antibody
      • KRS1 antibody
      • KRS2 antibody
      • Mammalian STE20 like protein kinase 1 antibody
      • Mammalian STE20 like protein kinase 2 antibody
      • MST 1 antibody
      • MST 2 antibody
      • MST1 antibody
      • MST2 antibody
      • Serine/threonine kinase 3 (STE20 homolog yeast) antibody
      • Serine/threonine kinase 3 (Ste20 yeast homolog) antibody
      • Serine/threonine kinase 3 antibody
      • Serine/threonine kinase 4 antibody
      • Serine/threonine protein kinase 3 antibody
      • Serine/threonine protein kinase 4 antibody
      • Serine/threonine protein kinase Krs 1 antibody
      • Serine/threonine protein kinase Krs 2 antibody
      • STE20 like kinase MST1 antibody
      • STE20 like kinase MST2 antibody
      • STK 3 antibody
      • STK 4 antibody
      • STK3 antibody
      • STK4 antibody
      • YSK3 antibody
      see all

    Anti-MST1/MST2 antibody 图像

    • Detection of Human MST1/2 by immunohistochemistry on formalin-fixed, paraffin-embedded Human placenta tissue using ab87322 at a dilution of 1/250.
      Detection: DAB staining.
    • Detection of Human MST1/2 by immunohistochemistry on formalin-fixed, paraffin-embedded Human colon carcinoma tissue, using ab87322 at a dilution of 1/250.
      Detection: DAB staining.

    Anti-MST1/MST2 antibody (ab87322)参考文献

    ab87322 has not yet been referenced specifically in any publications.

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