Anti-MSH3抗体[EPR4334(2)] (ab111107)


  • 产品名称Anti-MSH3抗体[EPR4334(2)]
    参阅全部 MSH3 一抗
  • 描述
    兔单克隆抗体[EPR4334(2)] to MSH3
  • 经测试应用适用于: IHC-P, ICC/IFmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human MSH3.

  • 阳性对照
    • Human colon adenocarcinoma and tonsil tissues; SW480 cells.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab111107 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/500 - 1/1000. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Heat up to 98 degrees C, below boiling, and then let cool for 10-20 min.
ICC/IF 1/250 - 1/500.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
    • 疾病相关Defects in MSH3 are a cause of susceptibility to endometrial cancer (ENDMC) [MIM:608089].
    • 序列相似性Belongs to the DNA mismatch repair mutS family. MSH3 subfamily.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Divergent upstream protein antibody
      • DNA mismatch repair protein antibody
      • DNA mismatch repair protein Msh 3 antibody
      • DNA mismatch repair protein MSH3 antibody
      • DUC 1 antibody
      • DUC1 antibody
      • DUG antibody
      • DUP antibody
      • hMSH3 antibody
      • MGC163306 antibody
      • MGC163308 antibody
      • Mismatch repair protein 1 antibody
      • MRP 1 antibody
      • MRP1 antibody
      • MSH 3 antibody
      • MSH3 antibody
      • MSH3_HUMAN antibody
      • MutS homolog 3 (E. coli) antibody
      • MutS homolog 3 antibody
      see all

    Anti-MSH3 antibody [EPR4334(2)] 图像

    • ab111107 at 1/500 dilution staining MSH3 in Paraffin-embedded Human colon adenocarcinoma tissue by Immunohistochemistry.
    • ab111107 at 1/500 dilution staining MSH3 in Paraffin-embedded Human Tonsil tissue by Immunohistochemistry.
    • ab111107 at 1/250 dilution staining MSH3 in SW480 cells by Immunofluorescence.

    Anti-MSH3 antibody [EPR4334(2)] (ab111107)参考文献

    ab111107 has not yet been referenced specifically in any publications.

    Product Wall

    I am afraid we do not have small samples of any of our antibodies. Antibody ab111107 may be specific for an epitope that exists only in the native conformation, as the western blot testing is carried out on reduced and denatured samples. We have not te...

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