概述

  • 产品名称Anti-MSF抗体
    参阅全部 MSF 一抗
  • 描述
    小鼠多克隆抗体to MSF
  • 特异性Reactive against mammalian transfected lysate.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length human MSF protein (NP_006631).

  • 阳性对照
    • HepG2 cell lysate; MSF transfected 293T cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab89160 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 65 kDa.

靶标

  • 功能Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
  • 组织特异性Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity. Isoform 5 is the most highly expressed in fetal tissue. Isoform 1 is detected in all tissues except the brain and thymus, while isoform 2, isoform 3, and isoform 4 are detected at low levels in approximately half of the fetal tissues.
  • 疾病相关Note=A chromosomal aberration involving SEPT9/MSF is found in therapy-related acute myeloid leukemia (t-AML). Translocation t(11;17)(q23;q25) with MLL.
    Defects in SEPT9 are a cause of hereditary neuralgic amyotrophy (HNA) [MIM:162100]; also known as neuritis with brachial predilection (NAPB) or hereditary brachial plexus neuropathy or hereditary neuralgic amyotrophy with predilection for brachial plexus. HNA is an autosomal dominant form of recurrent focal neuropathy characterized clinically by acute, recurrent episodes of brachial plexus neuropathy with muscle weakness and atrophy preceded by severe pain in the affected arm. HNA is triggered by environmental factors such as infection or parturition.
  • 序列相似性Belongs to the septin family.
  • 细胞定位Cytoplasm > cytoskeleton. In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes partly with actin stress fibers. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AF17q25 antibody
    • Cell division control protein septin D1 antibody
    • KIAA0991 antibody
    • MLL septin like fusion protein antibody
    • MLL septin-like fusion protein antibody
    • MLL septin-like fusion protein MSF-A antibody
    • MSF antibody
    • MSF1 antibody
    • NAPB antibody
    • Ov/Br septin antibody
    • Ovarian/breast septin alpha antibody
    • Ovarian/Breast septin antibody
    • PNUTL4 antibody
    • SEPT9 antibody
    • SEPT9_HUMAN antibody
    • SeptD1 antibody
    • Septin 9 antibody
    • Septin D1 antibody
    • Septin-9 antibody
    • SINT1 antibody
    see all

Anti-MSF antibody 图像

  • Anti-MSF antibody (ab89160) at 1/500 dilution + HepG2 cell lysate at 50 µg

    Predicted band size : 65 kDa
    Observed band size : ~65 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 73 kDa,76 kDa. We are unsure as to the identity of these extra bands.
  • All lanes : Anti-MSF antibody (ab89160) at 1/500 dilution

    Lane 1 : MSF transfected 293T lysate
    Lane 2 : Non transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 65 kDa

Anti-MSF antibody (ab89160)参考文献

ab89160 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab89160.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"