概述

  • 产品名称Anti-MRP8抗体[CF-145] (FITC)
    参阅全部 MRP8 一抗
  • 描述
    小鼠单克隆抗体[CF-145] to MRP8 (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 经测试应用适用于: ICC/IF, WB, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Purified granulocyte antigen of Human origin.

  • 阳性对照
    • Human Peripheral Blood Leukocytes

性能

应用

Our Abpromise guarantee covers the use of ab112213 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 11 kDa.
Flow Cyt Use 0.5µg for 106 cells. ab91368-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS) (By similarity). Promotes tubulin polymerization. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions.
  • 组织特异性Expressed by macrophages in chronic inflammations. Also expressed in epithelial cells constitutively or induced during dermatoses.
  • 序列相似性Belongs to the S-100 family.
    Contains 2 EF-hand domains.
  • 细胞定位Secreted. Cytoplasm. Cytoplasm > cytoskeleton. Cell membrane. Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes. Serum levels are high in patients suffering from chronic inflammation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 60B8Ag antibody
    • AI323541 antibody
    • B8Ag antibody
    • BEE11 antibody
    • CAGA antibody
    • Calgranulin-A antibody
    • Calprotectin L1L subunit antibody
    • Calprotectin, included antibody
    • CFAG antibody
    • CGLA antibody
    • Chemotactic cytokine CP-10 antibody
    • CP-10 antibody
    • Cystic fibrosis antigen antibody
    • L1Ag antibody
    • Leukocyte L1 complex light chain antibody
    • MA387 antibody
    • MIF antibody
    • Migration inhibitory factor-related protein 8 antibody
    • MRP-8 antibody
    • Myeloid-related protein 8 antibody
    • Neutrophil cytosolic 7 kDa protein antibody
    • NIF antibody
    • p8 antibody
    • Pro-inflammatory S100 cytokine antibody
    • Protein S100-A8 antibody
    • S100 calcium binding protein A8 (calgranulin A) antibody
    • S100 calcium binding protein A8 antibody
    • S100 calcium-binding protein A8 antibody
    • S100A8 antibody
    • S100A8/S100A9 complex, included antibody
    • S10A8_HUMAN antibody
    • Urinary stone protein band A antibody
    see all

Anti-MRP8 antibody [CF-145] (FITC) 图像

  • Cell Source: Human Peripheral Blood Leukocytes labeled with ab112213 at a concentration of 0.5µg/106 Cells.
    Percentage of cells stained above control: 99.9%.
    Isotypic Control (shaded): FITC Mouse IgG2b

Anti-MRP8 antibody [CF-145] (FITC) (ab112213)参考文献

This product has been referenced in:
  • Thacher SM  et al. Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes. Cell Growth Differ 10:255-62 (1999). Read more (PubMed: 10319995) »
  • Klein ES  et al. Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists. J Biol Chem 271:22692-6 (1996). Read more (PubMed: 8798442) »

See all 2 Publications for this product

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